{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:05:22Z","timestamp":1773176722513,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["21K03779"],"award-info":[{"award-number":["21K03779"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["20K07922"],"award-info":[{"award-number":["20K07922"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Semantic dementia (SD) is a unique clinicopathological entity associated with TDP\u2010type C pathology. We present four cases of SD that illustrate the clinicopathological diversity of TDP\u201043 pathology, including early\u2010onset cases of TDP\u2010type C with corticospinal tract (CST) and motor neuron pathology and late\u2010onset cases of TDP\u2010type A with combined pathology. Case 1 was a 62\u2010year\u2010old man with semantic variant of primary progressive aphasia (svPPA) with left\u2010predominant temporal atrophy and TDP\u2010type C pathology with low Alzheimer's disease neuropathologic changes (ADNC). Case 2 was a 63\u2010year\u2010old woman with right\u2010predominant temporal atrophy and TDP\u2010type C pathology who had prosopagnosia and personality changes. Phosphorylated(p)\u2010TDP\u201043\u2010positive long dystrophic neurites (DNs) were observed throughout the cerebral cortex; they were more abundant in the relatively spared cortices and less so in the severely degenerated cortices. We observed CST degeneration with TDP\u201043 pathology in the upper and lower motor neurons, without apparent motor symptoms, in SD with TDP\u2010type C pathology. Case 3 was a 76\u2010year\u2010old man who had svPPA and personality changes, with left\u2010predominant temporal atrophy and TDP\u2010type A pathology with high ADNC and argyrophilic grain (AG) stage 3. Case 4 was an 82\u2010year\u2010old man who had prosopagnosia and later developed symptoms of dementia with Lewy bodies (DLB) with right\u2010predominant temporal atrophy and TDP\u2010type A pathology with high ADNC, DLB of diffuse neocortical type, and AG stage 3. The distribution of p\u2010TDP\u201043\u2010positive NCIs and short DNs was localized in the anterior and inferior temporal cortices. An inverse relationship between the extent of TDP pathology and neuronal loss was also observed in SD with TDP\u2010type A pathology. In contrast, the extent of AD, DLB, and AG pathology was greater in severely degenerated regions. CST degeneration was either absent or very mild in SD with TDP\u2010type A. Understanding the clinicopathological diversity of SD will help improve its diagnosis and treatment.<\/jats:p>","DOI":"10.1111\/neup.12859","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T07:21:45Z","timestamp":1667805705000},"page":"5-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinicopathological diversity of semantic dementia: Comparisons of patients with early\u2010onset versus late\u2010onset, left\u2010sided versus right\u2010sided temporal atrophy, and TDP\u2010type A versus type C pathology"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4074-1041","authenticated-orcid":false,"given":"Shinobu","family":"Kawakatsu","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Aizu Medical Center Fukushima Medical University  Aizuwakamatsu City Japan"},{"name":"Department of Psychiatry Yamagata University School 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