{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:05:20Z","timestamp":1773896720262,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Here we present the autopsy case of an 80\u2010year\u2010old woman with a 9\u2010year history of motor neuron disease and atypical Parkinsonism. Her initial symptom was gait disturbance, and she subsequently developed limb weakness and Parkinsonism without response to levodopa. Her motor symptoms progressed to bulbar palsy, and she died of respiratory failure. Postmortem examination revealed characteristic findings of amyotrophic lateral sclerosis (ALS), including motor neuronal loss with astrogliosis, corticospinal tract degeneration, and TAR DNA\u2010binding protein of 43\u2009kDa abnormalities, including nuclear loss and skein\u2010like inclusions. In contrast, severe tau pathological changes were seen in the frontotemporal lobes and pallido\u2010nigral system. Tau pathologies affected not only neuronal components, such as neurofibrillary tangles and neuropil threads, but also glial cells (astrocytes and oligodendrocytes). Some glial tau pathologies exhibited peculiar round accumulations, reminiscent of globular glial inclusions (GGIs) in globular glial tauopathy. This unique autopsy case demonstrates that ALS with TDP\u201043 could be comorbid with globular glial tau inclusions and indicates that common pathological mechanisms exist among ALS and GGI formation.<\/jats:p>","DOI":"10.1111\/neup.12862","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T05:49:42Z","timestamp":1661406582000},"page":"117-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Amyotrophic lateral sclerosis with <scp>TDP<\/scp>\u201043 abnormalities exhibiting globular glial tau inclusions in frontotemporal lobes and pallido\u2010nigral system"],"prefix":"10.1111","volume":"43","author":[{"given":"Kaoru","family":"Yagita","sequence":"first","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naokazu","family":"Sasagasako","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuro\u2010Muscular Center National Omuta Hospital  Omuta Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideko","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-7248","authenticated-orcid":false,"given":"Hiroyuki","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical 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