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Age at surgery ranged from 7\u2009months to 72\u2009years (mean: 33\u2009years) affecting 246 male and 261 female patients. Colloid cyst was the most frequently resected cyst, followed by epidermoid cyst, arachnoid cyst, Rathke cleft cyst, dermoid cyst, neurenteric cyst, Tarlov cyst, and choroid plexus cyst. Diagnosis was based on the location of the cysts and the nature of the lining epithelium. Rathke cleft cyst showed the highest propensity for squamous metaplasia, significant inflammation, and xanthogranulomatous reaction. Ulceration of lining epithelium and calcification were most frequent in dermoid cyst. Radiopathological concordance was maximal for colloid cyst, followed by epidermoid and arachnoid cysts. Epidermoid and dermoid cysts exhibited the highest propensity for local tumor progression, followed by Rathke cleft cyst.<\/jats:p>","DOI":"10.1111\/neup.12867","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T11:51:52Z","timestamp":1665402712000},"page":"221-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nonneoplastic and noninfective cysts of the central nervous system: A histopathological study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6008-5534","authenticated-orcid":false,"given":"Rajalakshmi","family":"Poyuran","sequence":"first","affiliation":[{"name":"Department of Pathology Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)  Trivandrum India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viswanadh Sri Venkata Ganesh","family":"Kalaparti","sequence":"additional","affiliation":[{"name":"Department of Imaging Sciences &amp; Intervention Radiology Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)  Trivandrum India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bejoy","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Imaging Sciences &amp; Intervention Radiology Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)  Trivandrum India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnakumar","family":"Kesavapisharady","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)  Trivandrum India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-9018","authenticated-orcid":false,"given":"Deepti","family":"Narasimhaiah","sequence":"additional","affiliation":[{"name":"Department of Pathology Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)  Trivandrum India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2393050823"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1698033"},{"key":"e_1_2_5_4_1","first-page":"237","article-title":"Cysts of the central nervous system: A clinicopathologic study of 145 cases","volume":"49","author":"Sundaram C","year":"2001","journal-title":"Neurol India"},{"key":"e_1_2_5_5_1","first-page":"7","article-title":"Histological analysis of cystic tumour like lesions of central nervous system","volume":"45","author":"Sidhu M","year":"2002","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_5_6_1","first-page":"1937","article-title":"Retrospective analysis of cysts of central nervous system and review of literature","volume":"6","author":"Kaur DS","year":"2018","journal-title":"Sch J Appl Med Sci"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.18410\/jebmh\/2017\/1064"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1729782"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1978.48.3.0475"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1975.43.5.0614"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(02)01042-X"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.15.6.8577967"},{"key":"e_1_2_5_13_1","first-page":"5","article-title":"Surgery of intracranial epidermoid cysts. 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