{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:56:15Z","timestamp":1789005375957,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008883","name":"Nagoya City University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>Although many entities have been established within the broad spectrum of Parkinson disease (PD) and atypical parkinsonisms, they are often difficult to differentiate. To clarify the current clinical diagnostic conditions and problems in PD and atypical parkinsonisms, we analyzed volumes of the <jats:italic>Annuals of the Pathological Autopsy Cases in Japan<\/jats:italic>. Among 130\u2009105 autopsies conducted from 2007 to 2016 throughout Japan, patients were included in the study if they had been either clinically or pathologically diagnosed with PD, multiple system atrophy (MSA), progressive supranuclear palsy (PSP), or corticobasal degeneration (CBD). Autopsy rates were 6.4% for clinically diagnosed PD, 34.1% for MSA, 16.3% for PSP, and 17.4% for CBD. The specificities and sensitivities of clinical diagnoses were 88.0% and 82.0% for PD, 95.2% and 86.0% for MSA, 82.7% and 73.2% for PSP, and 55.4% and 57.7% for CBD, respectively. Clinical diagnoses had relatively high accuracy, but low autopsy rates are of concern. Many patients with rarer disorders were clinically misdiagnosed with PD, a more common disorder. Autopsy rates, irrespective of specific disorders, should be increased to detect rare diseases. Increasing autopsy rates will increase the available clinical information regarding pathologically confirmed patients and contribute to more accurate clinical diagnoses.<\/jats:p>","DOI":"10.1111\/neup.12876","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T07:44:50Z","timestamp":1667807090000},"page":"297-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A descriptive study of Parkinson disease and atypical parkinsonisms in the <i>Annuals of the Pathological Autopsy Cases in Japan<\/i>"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5133-281X","authenticated-orcid":false,"given":"Yoshihiko","family":"Horimoto","sequence":"first","affiliation":[{"name":"Department of Neurology Nagoya City Rehabilitation Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya City Rehabilitation Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chise","family":"Anan","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya City Rehabilitation Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayuko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya City Rehabilitation Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya City Rehabilitation Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Tajima","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya City Rehabilitation Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Hibino","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya City Rehabilitation Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology and Molecular Diagnostics Nagoya City University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"An Essay on the Shaking Palsy","author":"Parkinson J","year":"1817"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.8.1497"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.04.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz189"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.1.119"},{"key":"e_1_2_8_7_1","volume-title":"Annual of the Pathological Autopsy Cases in Japan","author":"Edited by The Japanese Society of Pathology","year":"2008"},{"key":"e_1_2_8_8_1","volume-title":"Annual of the Pathological Autopsy Cases in Japan","author":"Edited by The Japanese Society of Pathology","year":"2009"},{"key":"e_1_2_8_9_1","volume-title":"Annual of the Pathological Autopsy Cases in Japan","author":"Edited by The Japanese Society of Pathology","year":"2010"},{"key":"e_1_2_8_10_1","volume-title":"Annual of the Pathological Autopsy Cases in Japan","author":"Edited by The Japanese Society of Pathology","year":"2011"},{"key":"e_1_2_8_11_1","volume-title":"Annual of the Pathological Autopsy Cases in Japan","author":"Edited by The Japanese Society of Pathology","year":"2012"},{"key":"e_1_2_8_12_1","volume-title":"Annual of the Pathological Autopsy Cases in Japan","author":"Edited by The Japanese Society of Pathology","year":"2013"},{"key":"e_1_2_8_13_1","volume-title":"Annual of the Pathological Autopsy Cases in Japan","author":"Edited by The Japanese Society of Pathology","year":"2014"},{"key":"e_1_2_8_14_1","volume-title":"Annual of the Pathological Autopsy Cases in Japan","author":"Edited by The Japanese Society of Pathology","year":"2015"},{"key":"e_1_2_8_15_1","volume-title":"Annual of the Pathological Autopsy Cases in Japan","author":"Edited by The Japanese Society of Pathology","year":"2016"},{"key":"e_1_2_8_16_1","volume-title":"Annual of the Pathological Autopsy Cases in Japan","author":"Edited by The Japanese Society of Pathology","year":"2017"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157410"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827f0fd1"},{"key":"e_1_2_8_19_1","unstructured":"Ministry of Health Labour and Welfare of Japan Homepage. 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