{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:23:51Z","timestamp":1782509031531,"version":"3.54.5"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T00:00:00Z","timestamp":1670112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>Intracranial epidermoid cysts (ECs) occur at various locations along the neuraxis and account for nearly 2% of all intracranial tumors. Considering the frequency of ECs, transformation of ECs into squamous cell carcinomas is a rare occurrence. Here, we report the case of a 39\u2010year\u2010old man who presented with a lesion in the left cerebellopontine angle and underwent gross total resection for the same. Histopathological examination revealed a benign EC with mild chronic inflammation. Five months later, the patient presented with another lesion at the same location with evidence of brainstem bleed. Histopathological examination revealed a moderately differentiated squamous cell carcinoma and remnants of the previous cyst in the form of lamellated keratin, indicating malignant transformation of the EC.<\/jats:p>","DOI":"10.1111\/neup.12884","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T02:13:41Z","timestamp":1670206421000},"page":"268-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rapid malignant transformation of an intracranial epidermoid cyst: Report of a case"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-9018","authenticated-orcid":false,"given":"Deepti","family":"Narasimhaiah","sequence":"first","affiliation":[{"name":"Department of Pathology Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandran","family":"Kesavadas","sequence":"additional","affiliation":[{"name":"Department of Imaging Sciences and Interventional Radiology Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6008-5534","authenticated-orcid":false,"given":"Rajalakshmi","family":"Poyuran","sequence":"additional","affiliation":[{"name":"Department of Pathology Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.4.PEDS08489"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/abr.abr_107_16"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2015.11.039"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.750899"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.07.026"},{"key":"e_1_2_8_7_1","first-page":"226","article-title":"Haufung dysontogenetischer Bildungen am Zentralnervensystems","volume":"15","author":"Ernst P","year":"1912","journal-title":"Verh Dtsch Ges Pathol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.54.6.0824"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-5175-4"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/neup.12884","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T06:14:55Z","timestamp":1692425695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,4]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/neup.12884"],"URL":"https:\/\/doi.org\/10.1111\/neup.12884","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,4]]},"assertion":[{"value":"2022-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}