{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:59Z","timestamp":1747187159438,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>Polymorphous low\u2010grade neuroepithelial tumor of the young (PLNTY), one of the pediatric\u2010type diffuse low\u2010grade gliomas, is characterized by a diffuse infiltrating pattern of oligodendroglioma\u2010like tumor cells showing CD34 positivity and harbors mitogen\u2010activated protein kinase (MAPK) alteration, such as <jats:italic>vRAF murine sarcoma viral oncogene homolog B1<\/jats:italic> (<jats:italic>BRAF<\/jats:italic>) p.V600E or fibroblast growth factor fusion genetically. It occurs mainly in pediatric and adolescents with seizures due to the dominant location of the temporal lobe. However, there have been a few cases of PLNTY in adult patients, suggesting the wide range of this tumor spectrum. Here, we describe two cases of PLNTY, one in a 14\u2010year\u2010old female and the other in a 66\u2010year\u2010old female. The pediatric tumor showed typical clinical course and histopathology with <jats:italic>BRAF<\/jats:italic> p.V600E mutation, whereas the elderly tumor was unusual because of non\u2010epileptic onset clinically and ependymal differentiation histopathologically harboring <jats:italic>KIAA1549\u2010BRAF<\/jats:italic> fusion. There might be unusual but possible PLNTY, as in our elderly case. We also compared typical pediatric and unusual elderly tumors by reviewing the literature.<\/jats:p>","DOI":"10.1111\/neup.12889","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T09:18:31Z","timestamp":1671700711000},"page":"319-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pediatric and elderly polymorphous low\u2010grade neuroepithelial tumor of the young: Typical and unusual case reports and literature review"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-7818","authenticated-orcid":false,"given":"Takuya","family":"Furuta","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Moritsubo","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University 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