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Little has been reported on iron deposits in patients with PML. Herein, we report a case of PML with massive iron deposition in the juxtacortical regions attaching white matter lesions in a 71\u2010year\u2010old woman who developed bilateral visual disturbance and progressive aphasia after 16\u2009months of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone treatment for follicular lymphoma. Magnetic resonance imaging revealed white matter lesions in the left parietal and other lobes with massive iron deposition in the juxtacortical lesions. A PCR test for JC virus was positive, confirming the diagnosis of PML. Despite treatment with mefloquine and mirtazapine, the patient died six\u2009months later. At autopsy, demyelination was found dominantly in the left parietal lobe. Moreover, hemosiderin\u2010laden macrophages and reactive astrocytes containing ferritin were abundant in the juxtacortical regions adjacent to the white matter lesions. This is a previously unreported case of PML after lymphoma, in which iron deposition was confirmed both radiologically and pathologically.<\/jats:p>","DOI":"10.1111\/neup.12898","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:40:00Z","timestamp":1677505200000},"page":"396-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An autopsy case of progressive multifocal leukoencephalopathy with massive iron deposition in juxtacortical lesions"],"prefix":"10.1111","volume":"43","author":[{"given":"Kosuke","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Neurology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitoshi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Neurology Osaka Metropolitan University Graduate School of Medicine  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