{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:36:37Z","timestamp":1788791797921,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Somatic mosaicism of <jats:italic>isocitrate dehydrogenase 1\/2<\/jats:italic> (<jats:italic>IDH1\/2<\/jats:italic>) mutation is a cause of Ollier disease (OD), characterized by multiple enchondromatosis. A 35\u2010year\u2010old woman who was diagnosed with OD at age 24 underwent resection surgery for multifocal tumors located at the right and left frontal lobes that were discovered incidentally. No apparent spatial connection was observed on preoperative magnetic resonance imaging. Pathological examinations revealed tumor cells with a perinuclear halo in the left frontal lobe tumor, whereas astrocytic tumor cells were observed in the right frontal lobe tumor. Based on positive IDH1 R132H immunostaining and the result of 1p\/19q fluorescent <jats:italic>in situ<\/jats:italic> hybridization, pathological diagnoses were <jats:italic>IDH<\/jats:italic> mutant and 1p\/19q\u2010codeleted oligodendroglioma in the right frontal lobe tumor and <jats:italic>IDH<\/jats:italic> mutant astrocytoma in the left frontal lobe tumor, respectively. The DNA sequencing revealed <jats:italic>IDH1<\/jats:italic> R132H mutation in the peripheral blood sample and frontal lobe tumors. This case suggested that in patients with OD, astrocytoma and oligodendroglioma can co\u2010occur within the same individual simultaneously, and <jats:italic>IDH1<\/jats:italic> R132H mutation was associated with supratentorial development of gliomas.<\/jats:p>","DOI":"10.1111\/neup.12902","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T06:37:16Z","timestamp":1679380636000},"page":"413-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Supratentorial multifocal gliomas associated with Ollier disease harboring <scp><i>IDH1<\/i> R132H<\/scp> mutation: A case report"],"prefix":"10.1111","volume":"43","author":[{"given":"Hiroshi","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Hokkaido University School of Medicine  Sapporo 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