{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:46:03Z","timestamp":1747187163221,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>Neuronal intranuclear inclusions (NIIs) are common key structures in polyglutamine (polyQ) diseases such as Huntington disease (HD), spinocerebellar ataxia type 1 (SCA1), and SCA3. Marinesco bodies (MBs) of dopaminergic neurons in the substantia nigra are also intranuclear structures and are\u00a0frequently seen in normal elderly people. Ribosomal dysfunction is closely related to two differential processes; therefore, we aimed to identify the pathological characteristics of ribosomal protein SA (RPSA), a ribosomal protein, in both states. To this end, we evaluated the autopsy findings in four patients with HD, two SCA3, and five normal elderly cases (NCs). Immunohistochemical studies demonstrated that both NIIs and MBs contain RPSA. In polyQ diseases, RPSA was co\u2010localized with polyQ aggregations, and 3D\u2010reconstructed images revealed their mosaic\u2010like distribution. Assessments of the organization of RPSA and p62 in NIIs showed that RPSA was more localized toward the center than p62 and that this unique organization was more evident in the MBs. Immunoblotting of the temporal cortices revealed that the nuclear fraction of HD patients contained more RPSA than that of NCs. In conclusion, our study revealed that RPSA is a common component of both NIIs and MBs, indicating that a similar mechanism contributes to the formation of polyQ NIIs and MBs.<\/jats:p>","DOI":"10.1111\/neup.12927","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T09:05:14Z","timestamp":1687338314000},"page":"31-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ribosomal protein <scp>SA<\/scp> is a common component of neuronal intranuclear inclusions in polyglutamine diseases and Marinesco bodies"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3576-0049","authenticated-orcid":false,"given":"Kaoru","family":"Yagita","sequence":"first","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Sadashima","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideko","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideomi","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naokazu","family":"Sasagasako","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Hospital Organization Omuta National Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-7248","authenticated-orcid":false,"given":"Hiroyuki","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Neuropathology Center National Hospital Organization, Omuta National Hospital  Omuta Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1038\/nsmb1215"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1038\/nrn.2017.92"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1074\/jbc.M106575200"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1111\/nan.12253"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1111\/neup.12600"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1007\/s00401-012-0956-x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1111\/j.1365-2990.2011.01217.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1007\/s00401-012-0999-z"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1111\/neup.12050"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1111\/neup.12237"},{"key":"e_1_2_9_12_1","first-page":"1000","article-title":"Sur la pr\u00e9sence des corpuscles acidophiles paranucleolaires dans les cellules du locus nigeret du locus ceruleus","volume":"135","author":"Marinesco G","year":"1902","journal-title":"CR Acsd Sci (Paris)"},{"doi-asserted-by":"publisher","key":"e_1_2_9_13_1","DOI":"10.1136\/jnnp.26.2.178"},{"key":"e_1_2_9_14_1","first-page":"431","article-title":"The fine structure of the Marinesco body","volume":"88","author":"Leestma JE","year":"1969","journal-title":"Arch Pathol"},{"doi-asserted-by":"publisher","key":"e_1_2_9_15_1","DOI":"10.1111\/neup.12647"},{"doi-asserted-by":"publisher","key":"e_1_2_9_16_1","DOI":"10.1111\/j.1440-1789.2011.01267.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_17_1","DOI":"10.1038\/s41392-021-00728-8"},{"doi-asserted-by":"publisher","key":"e_1_2_9_18_1","DOI":"10.1002\/wrna.1632"},{"doi-asserted-by":"publisher","key":"e_1_2_9_19_1","DOI":"10.1016\/j.molcel.2016.07.022"},{"doi-asserted-by":"publisher","key":"e_1_2_9_20_1","DOI":"10.1016\/j.celrep.2017.04.029"},{"doi-asserted-by":"publisher","key":"e_1_2_9_21_1","DOI":"10.1073\/pnas.1204089109"},{"doi-asserted-by":"publisher","key":"e_1_2_9_22_1","DOI":"10.1074\/jbc.M403722200"},{"doi-asserted-by":"publisher","key":"e_1_2_9_23_1","DOI":"10.1126\/science.154.3757.1662"},{"doi-asserted-by":"publisher","key":"e_1_2_9_24_1","DOI":"10.1007\/s00401-012-1000-x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_25_1","DOI":"10.1016\/S0304-3940(03)00280-5"},{"doi-asserted-by":"publisher","key":"e_1_2_9_26_1","DOI":"10.1016\/j.cell.2017.08.009"},{"doi-asserted-by":"publisher","key":"e_1_2_9_27_1","DOI":"10.1038\/s42003-021-02360-2"},{"doi-asserted-by":"publisher","key":"e_1_2_9_28_1","DOI":"10.1006\/exnr.2002.8028"},{"doi-asserted-by":"publisher","key":"e_1_2_9_29_1","DOI":"10.1136\/jnnp.74.5.597"},{"doi-asserted-by":"publisher","key":"e_1_2_9_30_1","DOI":"10.1111\/brv.12170"},{"doi-asserted-by":"publisher","key":"e_1_2_9_31_1","DOI":"10.1093\/oxfordjournals.molbev.a026000"},{"doi-asserted-by":"publisher","key":"e_1_2_9_32_1","DOI":"10.1146\/annurev-biochem-060614-033917"},{"doi-asserted-by":"publisher","key":"e_1_2_9_33_1","DOI":"10.1016\/j.trecan.2016.03.002"},{"doi-asserted-by":"publisher","key":"e_1_2_9_34_1","DOI":"10.1093\/emboj\/cdg579"},{"doi-asserted-by":"publisher","key":"e_1_2_9_35_1","DOI":"10.1016\/j.molcel.2010.09.024"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T01:14:03Z","timestamp":1706836443000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/neup.12927"],"URL":"https:\/\/doi.org\/10.1111\/neup.12927","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2023,6,21]]},"assertion":[{"value":"2023-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}