{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:46:03Z","timestamp":1747187163800,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T00:00:00Z","timestamp":1688860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Syphilis is an infectious disease caused by the spirochete bacterium <jats:italic>Treponema pallidum<\/jats:italic>. Neurosyphilis results from the infection of the nervous system with <jats:italic>Treponema pallidum<\/jats:italic>, which can occur at any stage of syphilis. Neurosyphilis is often overlooked because of its rarity. Early\u2010stage neurosyphilis with brain mass formation is rare. We present a case of early\u2010stage neurosyphilis with prominent Epstein\u2013Barr virus (EBV)\u2010positive monoclonal lymphoplasmacytic proliferation in an immunocompetent patient. A 36\u2010year\u2010old man presented with a chief complaint of a progressively worsening headache, a newly developed skin rash, and a fever. Magnetic resonance imaging showed a mass lesion, which measured 18\u2009mm in diameter, in the left frontal lobe of the cerebrum. The patient underwent an emergency operation to remove the abscess. A pathological investigation revealed complex findings. There was an abscess in the cerebrum. Lymphoplasmacytic meningitis was also noted. In addition, a vaguely nodular lesion, which was composed of plasmacytoid and lymphoid cells, was observed around the abscess. Immunohistochemically, an anti\u2010Treponema pallidum antibody revealed numerous Treponemas around the abscess. In situ hybridization revealed that the plasmacytoid and lymphoid cells were Epstein\u2013Barr encoding region (EBER)\u2010positive; \u03ba\u2010positive cells were significantly more prevalent than \u03bb\u2010positive cells, suggesting light\u2010chain restriction. Postoperatively, parenteral antibiotics were administered for four\u2009weeks. The patient has been free of recurrence for two\u2009years since the surgery. No association between neurosyphilis and EBV\u2010positive lymphoplasmacytic proliferation has ever been reported. Mass formation in early\u2010stage neurosyphilis is an exceptionally rare event. The present case indicates that in syphilis patients, lymphoproliferative disorders that lead to mass formation may be caused by concomitant EBV reactivation. Furthermore, when treating patients with mass lesions of the central nervous system, it is important to check their medical history and perform laboratory screening for infectious diseases to avoid overlooking syphilis infections.<\/jats:p>","DOI":"10.1111\/neup.12934","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T06:49:19Z","timestamp":1688971759000},"page":"104-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>Epstein\u2013Barr<\/scp> virus\u2010positive monoclonal lymphoplasmacytic proliferation associated with neurosyphilis in an immunocompetent patient: A case report"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6243-139X","authenticated-orcid":false,"given":"Takashi","family":"Hibiya","sequence":"first","affiliation":[{"name":"Department of Pathology Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotaka","family":"Nagahama","sequence":"additional","affiliation":[{"name":"Department of Pathology Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniaki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyoshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyasu","family":"Otsu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Shimasaki","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Pathology Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Pathology Project for Molecular Targets Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Pathology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Shiokawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-1652","authenticated-orcid":false,"given":"Motoo","family":"Nagane","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Shibahara","sequence":"additional","affiliation":[{"name":"Department of Pathology Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,9]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Sexually Transmitted Disease Surveillance.Centers for Disease Control and Prevention [Updated April 12 2022.] Available from URL2020.https:\/\/www.cdc.gov\/std\/statistics\/2020\/overview.htm"},{"key":"e_1_2_8_3_1","unstructured":"Syphilis (in Japanse).Infectious Agents Surveillance Report (IASR) 2020. 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