{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:46:05Z","timestamp":1747187165436,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Neuropil\u2010like islands (NIs) are a histologic hallmark of glioneuronal tumors with neuropil\u2010like islands (GTNIs), but GTNIs are presently not considered a homogeneous entity. The essence of GTNI is likely its glial component, and NIs are now considered aberrant neuronal differentiation or metaplasia. The case we report herein is a 41\u2010year\u2010old woman who was synchronously affected by two brain tumors: one was a glioblastoma (glioblastoma multiforme, GBM), of isocitrate dehydrogenase (IDH)\u2010wild type, with NIs in the left parietal lobe, and the other was histologically a composite gangliocytoma (GC)\/anaplastic ganglioglioma (GG) with NIs in the right medial temporal lobe. While both tumors were genetically wild type for <jats:italic>IDH<\/jats:italic>, <jats:italic>histone H3<\/jats:italic>, and v\u2010raf murine sarcoma viral oncogene homolog B1 (<jats:italic>BRAF<\/jats:italic>), the former tumor, but not the latter, was mutated for telomerase reverse transcriptase promoter gene (<jats:italic>TERT<\/jats:italic>). A recent systematic study using DNA methylation profiling and next\u2010generation sequencing showed that anaplastic GG separate into other WHO tumor types, including IDH\u2010wild\u2010type GBM. It suggested a diagnostic scheme where an anaplastic GG is likely an IDH\u2010wild\u2010type GBM if it is a <jats:italic>BRAF<\/jats:italic> wild type, <jats:italic>IDH<\/jats:italic> wild type, and <jats:italic>TERT<\/jats:italic> promoter mutant tumor. The likely scenario in this patient is that the GBM results from the progression of GC\/anaplastic GG due to the superimposed <jats:italic>TERT<\/jats:italic> promoter mutation and the propagation of newly generated GBM cells in the contralateral hemisphere. A systematic analysis using DNA methylation profiling and next\u2010generation sequencing was not available in this study, but the common presence of NIs histologically noted in the two tumors could support this scenario. Although a sufficient volume of molecular and genetic testing is <jats:italic>sine qua non<\/jats:italic> for the accurate understanding of brain tumors, the importance of histologic observation cannot be overemphasized.<\/jats:p>","DOI":"10.1111\/neup.12939","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T06:11:03Z","timestamp":1693289463000},"page":"126-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuropil\u2010like islands are a possible pathogenetic link between glioblastoma and gangliocytoma\/ganglioglioma in a case of synchronous bilateral brain tumors"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4751-7691","authenticated-orcid":false,"given":"Keisuke","family":"Ishizawa","sequence":"first","affiliation":[{"name":"Department of Pathology Saitama Medical University  Moroyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010ichi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology\/Neurosurgery Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010ichi","family":"Tamaru","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical Center, Saitama Medical University  Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology\/Neurosurgery Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology\/Neurosurgery Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical University  Moroyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199905000-00002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5414\/NP300402"},{"key":"e_1_2_8_4_1","first-page":"30","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Kleihues P","year":"2007"},{"volume-title":"WHO Classification of Tumours of the Central Nervous System, Revised","year":"2016","author":"Louis DN","key":"e_1_2_8_5_1"},{"key":"e_1_2_8_6_1","series-title":"WHO classification of tumours series","volume-title":"WHO classification of tumours, central nervous system tumours","author":"The WHO classification of tumours editorial board","year":"2021"},{"key":"e_1_2_8_7_1","first-page":"473","article-title":"Genomic profiling of a case of glioneuronal tumor with neuropil\u2010like islands","volume":"76","author":"Tsuboi N","year":"2022","journal-title":"Acta Med Okayama"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0927-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0855-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-016-2224-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0760-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12847"},{"key":"e_1_2_8_13_1","series-title":"WHO classification of tumours series","first-page":"15","volume-title":"Chapter 2. 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Central Nervous System Tumours","author":"Brat DJ","year":"2021"},{"key":"e_1_2_8_14_1","first-page":"141","volume-title":"WHO Classification of Tumours of the Central Nervous System, Revised","author":"Becker AJ","year":"2016"},{"key":"e_1_2_8_15_1","first-page":"1028","article-title":"Rapid IDH1 gene mutation analysis for intraoperative pathological diagnosis","volume":"2","author":"Adachi J","year":"2014","journal-title":"JSM Neurosurg Spine"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-018-03016-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0721-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlac044"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.13011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0293-7"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871001)60:7<1519::AID-CNCR2820600719>3.0.CO;2-1"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003300000538"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3765"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T01:23:41Z","timestamp":1712021021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/neup.12939"],"URL":"https:\/\/doi.org\/10.1111\/neup.12939","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2023,8,28]]},"assertion":[{"value":"2023-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}