{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:44:48Z","timestamp":1784141088672,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Intravascular large B\u2010cell lymphoma can induce central nervous system manifestations, including strokes, due to small\u2010vessel occlusion caused by lymphoma cells. However, involvement in large\u2010sized vessels is rare. Here, we present an unusual autopsy case of an 88\u2010year\u2010old man showing a rapid transition from multiple strokes due to small vessel occlusion, typical of intravascular lymphoma, to progressive embolic strokes caused by the occlusion of major cerebral arteries. Magnetic resonance angiography demonstrated the major cerebral arteries associated with those multiple progressive strokes, including the right posterior cerebral artery, left anterior cerebral artery, and right middle cerebral artery, but the detectability was poor. A random skin biopsy at the abdomen confirmed the diagnosis of intravascular large B\u2010cell lymphoma. The patient died 106\u2009days after hospitalization despite intensive treatment. An autopsy revealed broad liquefactive necrosis in the area governed by the major cerebral arteries and multiple small infarctions caused by intravascular lymphoma cells in the small\u2010sized vessels. In addition, the major cerebral arteries showed multiple thromboembolism with partial organization and clusters of intravascular lymphoma cells. Notably, those cells were shown aggregated and attached along the vascular wall of the basilar artery, which might have caused focal hypercoagulation in the near vessels. This aggregation might have disseminated widely in the other major cerebral arteries. Moreover, the cluster of intravascular lymphoma cells in the basilar artery was positive for tumor necrosis factor \u03b1, and similar histopathology findings were observed in the splenic veins. However, the pathogenesis of this rare phenomenon involving these cells remains unknown. From a clinical perspective, we should consider the possibility that intravascular lymphoma cells may provoke similar progressive embolic strokes.<\/jats:p>","DOI":"10.1111\/neup.12940","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T07:03:34Z","timestamp":1691651014000},"page":"135-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An autopsy case of intravascular large B\u2010cell lymphoma showing a rapid transition to embolic strokes with occlusion of the major cerebral arteries"],"prefix":"10.1111","volume":"44","author":[{"given":"So","family":"Tando","sequence":"first","affiliation":[{"name":"Department of Pathology and Applied Neurobiology Kyoto Prefectural University of Medicine, Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Departments of Neurology National Hospital Organization Maizuru Medical Center  Maizuru Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Mizuhara","sequence":"additional","affiliation":[{"name":"Departments of Neurology National Hospital Organization Maizuru Medical Center  Maizuru Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Yuki","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto Kizugawa Hospital  Joyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto Kizugawa Hospital  Joyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Applied Neurobiology Kyoto Prefectural University of Medicine, Graduate School of Medical Science  Kyoto Japan"},{"name":"Department of Neurology North Medical Center Kyoto Prefectural University of Medicine  Yosano\u2010Gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Neurology North Medical Center Kyoto Prefectural University of Medicine  Yosano\u2010Gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8369-8800","authenticated-orcid":false,"given":"Kyoko","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Applied Neurobiology Kyoto Prefectural University of Medicine, Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29050237"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356682"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.05.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001215)89:12<2515::AID-CNCR1>3.0.CO;2-H"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.5847"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03660.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12751"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340000282"},{"key":"e_1_2_8_10_1","first-page":"707","article-title":"Intravascular lymphomatosis complicated with marked tumoral thrombosis of the brain venous system including dural sinuses. 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