{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T10:07:26Z","timestamp":1749550046310,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Subependymal giant cell astrocytoma (SEGA) is a low\u2010grade periventricular tumor that is closely associated with tuberous sclerosis complex (TSC). SEGA typically arises during the first two decades of life and rarely arises after the age of 20\u201325\u2009years. Nevertheless, it has also been reported that glioma histologically resembling SEGA, so\u2010called SEGA\u2010like astrocytoma, can arise in neurofibromatosis type 1 (NF1) patients, even in the elderly. Herein, we report a case of SEGA\u2010like circumscribed astrocytoma arising in the lateral ventricle of a 75\u2010year\u2010old woman. Whole\u2010exome sequencing revealed a somatic variant of <jats:italic>NF1<\/jats:italic>. Methylation array analysis led to a diagnosis of \u201cmethylation class glioblastoma, IDH\u2010wildtype, mesenchymal\u2010type (GBM, MES)\u201d with a high calibrated score (0.99). <jats:italic>EGFR<\/jats:italic> amplification, <jats:italic>CDKN2A\/B<\/jats:italic> homozygous deletion, chromosomal +7\/\u221210 alterations, and <jats:italic>TERT<\/jats:italic> promoter mutation, typical molecular abnormalities usually found in GBM, were also observed. While most reported cases of SEGA\u2010like astrocytoma have arisen in NF1 patients, the patient was neither TSC nor NF1. Near total removal was accomplished with endoscopic cylinder surgery. At the 36\u2010month follow\u2010up, there was no tumor recurrence without adjuvant therapies. This clinical behavior did not match GBM. SEGA\u2010like astrocytoma of the elderly is rare, and this is the oldest case reported so far. In addition, high\u2010grade molecular features found in circumscribed tumor remain unclear. Further investigations among larger series are needed for clarifying the underlying molecular mechanisms.<\/jats:p>","DOI":"10.1111\/neup.12948","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T05:11:42Z","timestamp":1698988302000},"page":"190-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>SEGA<\/scp>\u2010like circumscribed astrocytoma in a <scp>non\u2010NF1<\/scp> patient, harboring molecular profile of <scp>GBM<\/scp>. A case report"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-2425","authenticated-orcid":false,"given":"Seiji","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"},{"name":"Department of Diagnostic Pathology Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Tanikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Brain Disease Translational Research Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Fujinami","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaishi","family":"Sakomi","sequence":"additional","affiliation":[{"name":"Department of Pathology Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehito","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetics, Center for Medical Science Fujita Health University  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1046-6827","authenticated-orcid":false,"given":"Hideaki","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ichimura","sequence":"additional","affiliation":[{"name":"Department of Brain Disease Translational Research Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhito","family":"Mase","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"volume-title":"Central Nervous System Tumours; 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