{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:52:23Z","timestamp":1778698343840,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Astroblastoma, MN1\u2010altered, is a rare neoplasm of the central nervous system (CNS). This malignancy shares similar histopathological features with other CNS tumors, including ependymomas, making it challenging to diagnose. DNA methylation profiling is a new and robust technique that may be used to overcome this diagnostic hurdle. We report the case of a now 25\u2010year\u2010old female diagnosed with what was initially called an ependymoma located in the cervical spine at the age of 2\u2009years old. After initial resection, the tumor recurred multiple times and within 2\u2009years of diagnosis had disseminated disease throughout the brain and spinal cord. She has now undergone over two decades of treatment, including multiple surgical resections, radiation therapy, and administration of numerous chemotherapeutic agents. In 2021, the patient presented to our institution with lumbosacral radicular symptoms due to enlarging lesions within the lumbosacral spine. Reexamination of formalin\u2010fixed, paraffin\u2010embedded material from the patient's tumor using genomic DNA methylation profiling resulted in a diagnostic change from grade III anaplastic ependymoma to astroblastoma, MN1\u2010altered. This work describes another confirmed case of astroblastoma, MN1\u2010altered, to the growing body of literature.<\/jats:p>","DOI":"10.1111\/neup.12960","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T05:41:54Z","timestamp":1703223714000},"page":"278-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A case of disseminated spinal astroblastoma harboring a <scp>MAMLD1<\/scp>::<scp>BEND2<\/scp> fusion"],"prefix":"10.1111","volume":"44","author":[{"given":"Erin N.","family":"Walker","sequence":"first","affiliation":[{"name":"Neurosurgical Oncology Unit, Surgical Neurology Branch National Institutes of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"},{"name":"University of South Carolina School of Medicine Greenville  Greenville South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell T.","family":"Laws","sequence":"additional","affiliation":[{"name":"Neurosurgical Oncology Unit, Surgical Neurology Branch National Institutes of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Neurosurgical Oncology Unit, Surgical Neurology Branch National Institutes of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Quezado","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Center for Cancer Research National Cancer Institute  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Neurosurgical Oncology Unit, Surgical Neurology Branch National Institutes of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C.","family":"Burton","sequence":"additional","affiliation":[{"name":"Neurosurgical Oncology Unit, Surgical Neurology Branch National Institutes of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"},{"name":"Neuro\u2010Oncology Branch, Center for Cancer Research National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-018-1623-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7824"},{"key":"e_1_2_11_4_1","volume-title":"A Classification of Tumors of the Glioma Group on a Histogenetic Basis with a Correlation Study of Prognosis","author":"Bailey PCH","year":"1926"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1930.tb08230.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00391"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1745.131485"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-022-01371-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29302-8"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0689-3"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0243-4"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-022-05301-y"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature26000"},{"key":"e_1_2_11_15_1","article-title":"Distant dissemination of mixed low\u2010grade astroblastoma\u2010arteriovenous malformation after initial operation: A case report. 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