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Tumor cells, including the lipogenic cells, were immunoreactive for GFAP, S\u2010100 protein, ATRX, and p53. They were negative for IDH1\u2010R132H, BRAF V600E, synaptophysin, NeuN, p16, mismatch repair proteins, and CD34. The patient is free from recurrence at approximately two\u2009years postoperatively. This is the fifth reported case of NF1\u2010associated GC\u2010GB (the second adult case). <jats:italic>NF1<\/jats:italic> gene mutation might have played a role in the pathogenesis of lipogenic differentiation of GC\u2010GB. 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