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A total of 101 (40.2%) samples contained CNS tissue in varying amounts. The principal pathologic findings in the CNS tissue from ovarian mature teratomas were as follows: (i) CNS tissue tended to form a relatively thin, undulating, plate\u2010like structure that comprised the walls or septa of cystic tumors; (ii) most neurons were small or medium sized, and no CD34\u2010positive \u201cramifying cells\u201d were observed; (iii) cytoplasmic processes of some astrocytes closely surrounded the walls of capillaries, suggesting formation of a blood\u2013brain barrier; (iv) some ependymal cells exhibited a columnar shape and showed a pseudostratified arrangement, and these cells extended thick basal cytoplasmic processes into the neuropil; (v) a few choroid plexus epithelial cells showed melanin deposition, tubular transformation, or oncocytic changes; (vi) hamartoma\u2010like hyperplasia of arachnoid cells was noted beneath skin tissue; (vii) some CNS tissue showed formation of cerebral cortical structures exhibiting \u201cgyration\u201d with incompletely layered structures, and disruption of the glia limitans with spillage of cortical tissue into the \u201csubarachnoid\u201d space was also observed; and (viii) in the well\u2010formed cerebellar cortex, dendrites of Purkinje cells exhibited varied dysmorphic changes. These neuropathologic observations should lead to a deeper understanding of the pathogenesis of various lesions in the brain.<\/jats:p>","DOI":"10.1111\/neup.13000","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T07:55:27Z","timestamp":1727942127000},"page":"109-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Central nervous tissue in ovarian mature teratoma: A neuropathological study of 101 resected tumors"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-9293","authenticated-orcid":false,"given":"Masayuki","family":"Shintaku","sequence":"first","affiliation":[{"name":"Department of Pathology Kansai Medical University Hospital  Hirakata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700400102"},{"key":"e_1_2_14_3_1","first-page":"1937","volume-title":"Pathology of the Nervous System","author":"Willis RA","year":"1971"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21050"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31824a1de2"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12732"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0693-7"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001045"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353982"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1891-8"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12360"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/90.4.397"},{"key":"e_1_2_14_13_1","first-page":"303","article-title":"Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells","volume":"66","author":"Tohyama T","year":"1992","journal-title":"Lab Invest"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90226-U"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051017"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197501092920202"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.66"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0178-9"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196801)21:1<38::AID-CNCR2820210108>3.0.CO;2-L"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198105000-00007"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686623"},{"key":"e_1_2_14_22_1","first-page":"88S","article-title":"Benign ovarian cystic teratomas with homunculi","volume":"61","author":"Weldon\u2010Linne CM","year":"1983","journal-title":"Obstet Gynecol"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.5858\/2006-130-1552-FTH"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050660"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00999-2"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001249"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116608"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.488"},{"key":"e_1_2_14_29_1","first-page":"383","article-title":"Human teratomas express differentiated neural antigens. 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