{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:46:13Z","timestamp":1747187173595,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>The case of a 75\u2010year\u2010old man with a glioblastoma of the right frontal lobe showing features of adenoid glioblastoma is reported. The tumor consisted of two components: the adenoid component, in which large, cohesive, polygonal cells with vesicular nuclei and abundant basophilic cytoplasm showed nest\u2010like, trabecular, or tubular growth on the myxoid matrix and formed a multinodular configuration; and the subsidiary component, in which short spindle cells showed compact fascicular growth. The features of ordinary glioblastoma were also found in a small area. Tumor cells were immunoreactive for S\u2010100 protein, glial fibrillary acidic protein, and Olig2, and some tumor cells in the adenoid component showed immunoreactivity for cytokeratins and E\u2010cadherin. A marked regional decrease in microvascular density, approaching almost complete absence of microvessels, was demonstrated in the adenoid component. In contrast, microvascular density was well preserved in the spindle cell component and the area of ordinary glioblastoma. Tumor cells in the adenoid component showed cytoplasmic expression of chondromodulin\u2010I, one of the cytokines that strongly inhibit angiogenesis, whereas the expression of this protein was very weak or only faint in the spindle cell component and the area of ordinary glioblastoma. A marked regional decrease in microvascular density was associated with myxoid change of the stroma and considered to be caused by the secretion of chondromodulin\u2010I by tumor cells. Stromal hypovascularity with myxoid change might play an important role in the morphogenesis of adenoid features.<\/jats:p>","DOI":"10.1111\/neup.13010","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T04:50:51Z","timestamp":1730695851000},"page":"153-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adenoid glioblastoma: Stromal hypovascularity and secretion of chondromodulin\u2010I by tumor cells"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-9293","authenticated-orcid":false,"given":"Masayuki","family":"Shintaku","sequence":"first","affiliation":[{"name":"Department of Pathology Kansai Medical University Hospital  Hirakata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Hashiba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kansai Medical University Hospital  Hirakata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kansai Medical University Hospital  Hirakata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kansai Medical University Hospital  Hirakata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Tsuta","sequence":"additional","affiliation":[{"name":"Department of Pathology Kansai Medical University Hospital  Hirakata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,3]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"39","volume-title":"Central Nervous System Tumours","author":"Louis DN","year":"2021"},{"key":"e_1_2_8_3_1","first-page":"139","article-title":"The clinical significance of \u201cadenoid\u201d formations of neoplastic astrocytes, imitating metastatic carcinoma, in gliosarcomas. A review of five cases","volume":"1","author":"Kepes JJ","year":"1982","journal-title":"Clin Neuropathol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23899"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.32419"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1476"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03225-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90115-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2003.tb00013.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199101033240101"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64097-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198803000-00002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02478901"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198610000-00009"},{"key":"e_1_2_8_15_1","first-page":"997","article-title":"Fine structure of glioblastoma multiforme with \u201cadenoid formation","volume":"16","author":"Shintaku M","year":"1988","journal-title":"Neurosurgery (Tokyo)"},{"key":"e_1_2_8_16_1","first-page":"359","article-title":"Adenoid\u201d glioblastoma","volume":"28","author":"Shintaku M","year":"2000","journal-title":"Neurosurgery (Tokyo)"},{"key":"e_1_2_8_17_1","first-page":"141","article-title":"Phenotypic and genotypic characterization of glioblastoma multiforme with epithelial differentiation and adenoid formations","volume":"23","author":"Du Plessis DG","year":"2004","journal-title":"Clin Neuropathol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2005.01835.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-005-0173-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31827f9c5e"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5858\/1999-123-0917-EOEAKM"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101430050030"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013665"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2012.758123"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198803000-00003"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860901)58:5<1061::AID-CNCR2820580514>3.0.CO;2-7"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2432664"},{"key":"e_1_2_8_28_1","first-page":"7393","article-title":"Immunohistochemical localization of basic fibroblast growth factor in astrocytomas","volume":"50","author":"Zagzag D","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/359845a0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2175"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-01892-8"},{"key":"e_1_2_8_32_1","first-page":"471","article-title":"The role of astrocytes in the formation of cartilage in gliomas. An immunohistochemical study of four cases","volume":"117","author":"Kepes JJ","year":"1984","journal-title":"Am J Pathol"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7629"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12057"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.13010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T06:15:46Z","timestamp":1743747346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.13010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,3]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/neup.13010"],"URL":"https:\/\/doi.org\/10.1111\/neup.13010","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2024,11,3]]},"assertion":[{"value":"2024-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}