{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:35:00Z","timestamp":1777476900106,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009667","name":"School of Medicine, Kyorin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Angiocentric glioma (AG) is a supratentorial diffuse low\u2010grade glioma characterized by the <jats:italic>MYB<\/jats:italic>::<jats:italic>QKI<\/jats:italic> fusion gene, showing angiocentric growth of monomorphous spindle cells with astrocytic and ependymal immunophenotypes. We describe a rare case of <jats:italic>MYB<\/jats:italic>::<jats:italic>QKI<\/jats:italic> fusion\u2010positive diffuse cerebellar glioma in a 54\u2010year\u2010old male. The patient initially presented with a T2\/FLAIR hyperintense lesion in the left cerebellar hemisphere and slowly progressive neurological symptoms. Histopathological evaluation revealed a diffuse glioma characterized by spindle\u2010shaped and small epithelioid cells with perivascular infiltration. Immunohistochemistry showed positivity for glial fibrillary acidic protein and only occasionally positive for Olig2. No dot\u2010 or ring\u2010like epithelial membrane antigen immunoreactivity was observed. In this case, the proliferative activity was higher than that in typical AG cases, as manifested by multiple mitoses (four mitoses\/slide) and a Ki\u201067 labeling index of 5%. The tumor cells were negative for IDH1 p.R132H and H3 p.K28M mutation\u2010specific antibodies. Fluorescence <jats:italic>in situ<\/jats:italic> hybridization showed a <jats:italic>MYB<\/jats:italic> break\u2010apart signal, and reverse transcription\u2010polymerase chain reaction analysis confirmed an in\u2010frame <jats:italic>MYB<\/jats:italic> (6q23.3, exon 11, NM_001161659.2)::<jats:italic>QKI<\/jats:italic> (6q26, exon 5, NM_006775.3) fusion. <jats:italic>IDH1<\/jats:italic> p.R132, <jats:italic>IDH2<\/jats:italic> p.R172, <jats:italic>H3\u20103A<\/jats:italic> p.K28, <jats:italic>H3C2<\/jats:italic> p.K28, and <jats:italic>BRAF<\/jats:italic> p.V600 were all wild type. DNA methylome profiling did not match any of the established methylation classes, including the four subtypes of diffuse glioma, <jats:italic>MYB\u2010<\/jats:italic> or <jats:italic>MYBL1<\/jats:italic>\u2010altered. Considering the results of DNA methylome profiling, the question remains as to whether this case represents a subset of AG (diffuse glioma, <jats:italic>MYB\/MYBL1<\/jats:italic>\u2010altered) or a distinct subtype. Although the morphological findings and the presence of fusion indicated that the tumor was a cerebellar AG, the DNA methylome profile did not match that of AG. An accumulation of more cases is needed to determine the precise nature of the tumor, which may lead to an expansion of the tumor concept.<\/jats:p>","DOI":"10.1111\/neup.13016","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T12:05:07Z","timestamp":1732190707000},"page":"228-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp><i>MYB<\/i>::<i>QKI<\/i><\/scp> fusion\u2010positive diffuse glioma of the cerebellum: A case report"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-5822","authenticated-orcid":false,"given":"Kaishi","family":"Satomi","sequence":"first","affiliation":[{"name":"Department of Pathology Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Department of Pathology Kyorin 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