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CERAD amyloid \u03b2 (A\u03b2) plaques, Braak tau neurofibrillary tangles, and Thal A\u03b2 plaque location are major scoring systems for quantifying neuropathological features of AD. We examined the association of late\u2010life systolic BP (SBP) with CERAD, Braak, and Thal in the National Alzheimer's Coordinating Center (NACC) Neuropathology Dataset. Of 1978 participants with data on CERAD, 762 had scores 0\u20131 (none to sparse) and 1216 had 2\u20133 (moderate to frequent). Of 1947 with data on Braak, 411 had stages 0\u2013II (normal to mild) and 1536 had III\u2013VI (moderately to very severe). Of 2132 with data on Thal, 438 had phases 0\u2013I, 428 II\u2013III, and 1266 IV\u2013V. Using the mean of the last four SBP before death, SBP was categorized into &lt;120 (references), 120\u2013139, and \u2265140\u2009mmHg. Age\u2010sex\u2010adjusted ORs (95% CIs) associated with SBP \u2265140\u2009mmHg for CERAD 2\u20133 and Braak III\u2013VI were 1.37 (1.03, 1.83, <jats:italic>P<\/jats:italic>\u2009=\u20090.03) and 1.26 (0.89, 1.78, <jats:italic>P<\/jats:italic>\u2009=\u20090.20), respectively. Similar association was observed for Thal II\u2013III and IV\u2013V. These associations essentially remained unchanged after additional adjustment for APOE and Lewy Body pathology. These findings suggest that higher late\u2010life SBP is associated with markers of presence and severity of neuropathological features of AD. Further studies with larger sample sizes are necessary to confirm the findings.<\/jats:p>","DOI":"10.1111\/neup.13029","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T01:24:17Z","timestamp":1738805057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of late\u2010life blood pressure with <scp>CERAD<\/scp>, <scp>Braak<\/scp>, and <scp>Thal<\/scp>: Findings from the <scp>National Alzheimer's<\/scp> coordinating center neuropathology dataset"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7482-1782","authenticated-orcid":false,"given":"Mo\u2010Kyung","family":"Sin","sequence":"first","affiliation":[{"name":"College of Nursing Seattle University  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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