{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:23:37Z","timestamp":1755217417958,"version":"3.43.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Choroid plexus tumors are neuroepithelium\u2010derived tumors arising in the ventricles of the central nervous system. They are commonly seen in childhood and correspond to low rates in all central nervous system tumors. Due to their rareness and similar histomorphologic features to other tumors, their diagnosis might be challenging. Here, we used the OTX\u20102 antibody to evaluate the diagnostic role of OTX\u20102 expression in choroid plexus tumors. We performed a retrospective review of 34 patients operated for choroid plexus tumors in our center between 2011 and 2023. Additionally, as different tumor types are also arising in the ventricles, we selected five cases each of AT\/RT, germ cell tumor, ependymoma, and metastatic adenocarcinoma from the pathology archive. Immunohistochemistry conditions were adjusted for each specific antibody based on the manufacturers' recommendations for concentrations and antigen retrieval\/blocking. OTX\u20102, S\u2010100, and transthyretin antibody staining was performed on sections from each case.<\/jats:p>","DOI":"10.1111\/neup.70001","type":"journal-article","created":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T20:48:27Z","timestamp":1740343707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["OTX\u20102 Expression as a Diagnostic Marker for Choroid Plexus Tumors"],"prefix":"10.1111","volume":"45","author":[{"given":"Ay\u00e7a","family":"Er\u015fen Danyeli","sequence":"first","affiliation":[{"name":"Pathology Department Acibadem University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"H\u00fcseyino\u011flu","sequence":"additional","affiliation":[{"name":"Neurosurgery Department Acibadem University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Memet","family":"\u00d6zek","sequence":"additional","affiliation":[{"name":"Neurosurgery Department Acibadem University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-014-1616-x"},{"volume-title":"Central Nervous System Tumours","year":"2021","author":"WHO Classification of Tumours Editorial Board","key":"e_1_2_9_3_1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20010101)52:1<5::AID-JEMT3>3.0.CO;2-J"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3921"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20010101)52:1<104::AID-JEMT12>3.0.CO;2-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000176430.88702.e0"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"368","article-title":"Transthyretin as a Potential Biomarker for the Differential Diagnosis Between Lung Cancer and Lung Infection","volume":"2","author":"Wang H.","year":"2014","journal-title":"Biomedical Reports"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.090860"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"32","article-title":"OTX2 Defines a Subgroup of Atypical Teratoid Rhabdoid Tumors With Close Relationship to Choroid Plexus Tumors","volume":"76","author":"Japp A. S.","year":"2017","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.3179"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0262-18.2019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.05.092"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000154"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:38:04Z","timestamp":1754397484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.70001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,23]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/neup.70001"],"URL":"https:\/\/doi.org\/10.1111\/neup.70001","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2025,2,23]]},"assertion":[{"value":"2024-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70001"}}