{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T15:01:08Z","timestamp":1768834868497,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A 79\u2010year\u2010old former professional football player presented with language deficits and cognitive changes. A year later, he had difficulty completing sentences, and 3\u2009years after onset, was reduced to one\u2010word answers. He developed severe apathy and agitation, and became more impulsive. He eventually became mute and had difficulty with walking and balance. The patient had mild repetitive head injury while playing football and three concussions. Magnetic resonance imaging revealed left\u2009&gt;\u2009right frontotemporal atrophy. Duration of illness was 6\u2009years. Neuropathology revealed an unexpected number and diversity of degenerative pathologies, including chronic traumatic encephalopathy (CTE, high level), high level Alzheimer's disease neuropathologic change (A3B3C3), limbic Lewy body disease, cerebral amyloid angiopathy (type 2), argyrophilic grain disease (Stage 2), and neuronal intranuclear hyaline inclusion body disease. In addition, there was selective and asymmetric involvement of the corticospinal tract with globular oligodendroglial tau pathology corresponding to globular glial tauopathy (Type II). The patchy and irregular accentuation of cortical tau pathology, particularly in the depths of sulci and accumulation around blood vessels, allows the diagnosis of CTE\u2010neuropathologic change. This diagnosis correlated with the past medical history of multiple concussions. In addition, the patient had an unprecedented number and combination of additional degenerative pathologies, including those that are rare, and how they contributed to the clinical symptoms is difficult to interpret. Globular glial tauopathy Type II is a rare disorder that has been mostly reported in association with progressive supranuclear gaze palsy, and these observations support the notion that globular glial tauopathy Type II is an independent entity with isolated corticospinal tract involvement. These observations highlight that rare disorders can occur in the same individual and be overlooked, especially when there is more obvious pathology. It is essential for neuropathologists to consider an extensive array of neuropathological examinations when assessing patients with neurodegenerative disorders.<\/jats:p>","DOI":"10.1111\/neup.70004","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T05:55:42Z","timestamp":1741845342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unprecedented Combination of Rare Degenerative Pathologies in an Octogenarian Ex\u2010Football Player"],"prefix":"10.1111","volume":"45","author":[{"given":"Shelley L.","family":"Forrest","sequence":"first","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Disease University of Toronto  Toronto Canada"},{"name":"Laboratory Medicine Program &amp; Krembil Brain Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nusrat","family":"Sadia","sequence":"additional","affiliation":[{"name":"Canadian Concussion Centre, Krembil Brain Institute, University Health Network University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mozhgan","family":"Khodadadi","sequence":"additional","affiliation":[{"name":"Canadian Concussion Centre, Krembil Brain Institute, University Health Network University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Tator","sequence":"additional","affiliation":[{"name":"Canadian Concussion Centre, Krembil Brain Institute, University Health Network University of Toronto  Toronto Canada"},{"name":"Division of Neurosurgery, Toronto Western Hospital University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Green","sequence":"additional","affiliation":[{"name":"Canadian Concussion Centre, Krembil Brain Institute, University Health Network University of Toronto  Toronto Canada"},{"name":"KITE\u2010Toronto Rehab University Centre  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Canadian Concussion Centre, Krembil Brain Institute, University Health Network University of Toronto  Toronto Canada"},{"name":"University Health Network Memory Clinic &amp; Krembil Brain Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-5511","authenticated-orcid":false,"given":"Gabor G.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Disease University of Toronto  Toronto Canada"},{"name":"Laboratory Medicine Program &amp; Krembil Brain Institute University Health Network  Toronto Canada"},{"name":"Edmond J. 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