{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:24:09Z","timestamp":1791843849883,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Monocarboxylate transporters (MCTs) are crucially implicated in cancer cell metabolism by transporting lactate\/H+ ions and thus regulating the pH of the microenvironment. We assessed MCT1 and MCT4 expression in 98 cases of adult\u2010type hemispheric Glioblastomas (GBMs) (IDH wild\u2010type), along with 51 cases of IDH\u2010mutant astrocytic and oligodendroglial tumors (grade 2\u20134) for comparison. U87MG and LN229 cell lines were used for in\u00a0vitro analysis. Both MCT\u20101 and MCT\u20104 showed significantly higher expression in GBMs on immunohistochemistry than in IDH\u2010mutated gliomas, which mostly showed weak or negative immunoreactivity. The mRNA expression was also in a similar line. Interestingly, in all areas of the pathological endothelial proliferation of grade 4 tumors, there was MCT\u20101 loss of expression, unlike the nonproliferating endothelium. High MCT1\/4 expression was associated with shorter overall survival in all gliomas together but not in GBM\u00a0separately. Syrosingopine, a dual MCT1\/4 inhibitor, showed significant antitumor effects in both the glioma cell lines, including dose\u2010dependent cytotoxicity, increased apoptosis, and decreased migration\/invasion. The results indicated the role of MCT1\/4 in the pathobiology of GBM and the diagnostic utility at the immunohistochemical level. Syrosingopine, an antihypertensive agent with good CNS penetration and previously used in different malignancies, may be an essential therapeutic adjunct in GBM.<\/jats:p>","DOI":"10.1111\/neup.70006","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T05:51:57Z","timestamp":1743054717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Monocarboxylate Transporters <scp>MCT1<\/scp> and <scp>MCT4<\/scp> Are Highly Expressed in Glioblastoma and Crucially Implicated in the Pathobiology"],"prefix":"10.1111","volume":"45","author":[{"given":"Minakshi M.","family":"Behera","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Lab Medicine All India Institute of Medical Sciences  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-5540","authenticated-orcid":false,"given":"Suvendu","family":"Purkait","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; 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