{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:23:33Z","timestamp":1755217413091,"version":"3.43.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Peripheral nerve injuries (PNI) cause a partial or total deficit of sensory and motor function, producing neuropathic pain and loss of productivity in adults. Type I collagen polymerized with polyvinylpyrrolidone (CLG\u2010PVP) has been used previously in other fibrosing diseases due to its regulatory effects on interleukins, cytokines, and adhesion molecules. In the present study, we describe the role of CLG\u2010PVP in the repair of PNI. We used a murine model of PNI through axonotmesis of the sciatic nerve. CLG\u2010PVP treatments were administered in\u00a0situ and intramuscularly and were compared to a sham procedure and placebo. Histological and histochemical\u2010specific stain evaluations were performed to describe the structural changes in nervous tissue. A significant reduction in tissue fibrosis was observed in the groups treated with CLG\u2010PVP, especially with the intramuscular treatment. Likewise, an increase in the organization of external lamina and nerve remyelination was observed in the treated groups. In addition, a slight improvement in gait was noted in the treated animal groups at the end of the study. After peripheral nerve injury, CLG\u2010PVP restores the nerve's function, structure, and tissue organization. These therapeutic effects were more evident through the intramuscular administration scheme with a weekly dosage. However, randomized controlled clinical trials should be performed to verify its beneficial effects and characterize adverse events.<\/jats:p>","DOI":"10.1111\/neup.70012","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T18:19:13Z","timestamp":1748283553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polymerized Type I Collagen With Polyvinylpyrrolidone Reduces Fibrosis and Improves Nerve Organization and Myelination After Peripheral Nerve Injury"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-0854","authenticated-orcid":false,"given":"Daniel","family":"Salas\u2010Trevi\u00f1o","sequence":"first","affiliation":[{"name":"Servicio de Infectolog\u00eda Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Soto\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Departamento de Histolog\u00eda, Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"de Oca\u2010Luna Montes","sequence":"additional","affiliation":[{"name":"Departamento de Histolog\u00eda, Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-1437","authenticated-orcid":false,"given":"Cynthia Minerva","family":"Gonz\u00e1lez\u2010Cant\u00fa","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda Pl\u00e1stica, Est\u00e9tica y Reconstructiva Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Everardo","family":"Vald\u00e9s\u2010Flores","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda Pl\u00e1stica, Est\u00e9tica y Reconstructiva Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio Manuel","family":"Garc\u00eda\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Humana Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1559-7814","authenticated-orcid":false,"given":"Yanko","family":"Castro\u2010Govea","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda Pl\u00e1stica, Est\u00e9tica y Reconstructiva Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020918"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24538"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199807000-00025"},{"issue":"6","key":"e_1_2_10_5_1","first-page":"527","article-title":"Estudio de la Lesi\u00f3n Nerviosa Perif\u00e9rica en Pacientes Atendidos por Traumatismos","volume":"150","author":"Castillo\u2010Galv\u00e1n M. 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