{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:23:37Z","timestamp":1755217417063,"version":"3.43.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Spinal astroblastoma is an exceedingly rare entity characterized by features that overlap with other spinal cord tumors. We present a case of a 67\u2010year\u2010old male who presented with trunk dysesthesia, motor weakness, and progressive hypoesthesia in both lower limbs. Magnetic resonance imaging (MRI) revealed edematous changes in the spinal cord at the C6\u2013Th1 level on T2\u2010weighted sequences, with a centrally enhancing lesion at the C7 level on gadolinium\u2010enhanced T1\u2010weighted imaging. Consistent with previous reports, spinal astroblastomas frequently involve the cervical and thoracic regions. Pathological examination in our case revealed pseudopapillary cellular arrangements surrounding hyalinized microvasculature. Immunohistochemical analysis demonstrated retained INI1\/SMARCB1 expression and mixed\u2010origin features, with positive staining for EMA, GFAP, OLIG2, neurofilament, and synaptophysin. The tumor exhibited low\u2010grade characteristics, with no mitotic activity, necrosis, or significant MIB\u20101 index (0.3%), and followed a gradual clinical course. Genetic profiling revealed no MN1 alteration or fusion genes. Based on these findings, a diagnosis of low\u2010grade spinal astroblastoma, not elsewhere classified, was made. In conclusion, spinal astroblastoma should be considered in the differential diagnosis of primary intramedullary spinal cord tumors, particularly those located in the cervicothoracic region and exhibiting mixed\u2010origin features. The sharing of cases among clinicians is crucial for enhancing awareness and understanding of this rare pathology.<\/jats:p>","DOI":"10.1111\/neup.70016","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T02:18:49Z","timestamp":1749003529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low\u2010Grade Primary Intramedullary Spinal Cord Astroblastoma: A Case Report and Literature Review"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-0942","authenticated-orcid":false,"given":"Irfan","family":"Kesumayadi","sequence":"first","affiliation":[{"name":"Divison of Neurosurgery, Department of Brain and Neurosciences, Faculty of Medicine Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-5915","authenticated-orcid":false,"given":"Atsushi","family":"Kambe","sequence":"additional","affiliation":[{"name":"Divison of Neurosurgery, Department of Brain and Neurosciences, Faculty of Medicine Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Uno","sequence":"additional","affiliation":[{"name":"Divison of Neurosurgery, Department of Brain and Neurosciences, Faculty of Medicine Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Divison of Neurosurgery, Department of Brain and Neurosciences, Faculty of Medicine Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Makishima","sequence":"additional","affiliation":[{"name":"Divison of Pathology, Department of Pathology Faculty of Medicine, Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8805-4440","authenticated-orcid":false,"given":"Makoto","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Divison of Neurosurgery, Department of Brain and Neurosciences, Faculty of Medicine Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurosaki","family":"Masamichi","sequence":"additional","affiliation":[{"name":"Divison of Neurosurgery, Department of Brain and Neurosciences, Faculty of Medicine Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-020-00372-0"},{"volume-title":"A Classification of the Tumors of the Glioma Group on a Histogenetic Basis With a Correlated Study of Prognosis","year":"1926","author":"Bailey P.","key":"e_1_2_11_3_1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.83.3.0550"},{"volume-title":"Brain Tumors: Their Biology and Pathology","year":"2013","author":"Z\u00fclch K. J.","key":"e_1_2_11_5_1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.9.SPINE161302"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12965"},{"issue":"150","key":"e_1_2_11_8_1","first-page":"1","article-title":"Primary Intramedullary Spinal Cord Astroblastoma With EWSR1\/BEND2 Fusion: A Case Report and Literature Review","volume":"6","author":"Lim M. S. M. C.","year":"2023","journal-title":"Neurosurg Cases and Reviews"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02388-y"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-022-05468-w"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12814"},{"key":"e_1_2_11_12_1","first-page":"2","article-title":"Molecular Clarification of Brainstem Astroblastoma With EWSR1\u2010BEND2 Fusion in a 38\u2010Year\u2010Old Man","volume":"2","author":"Smith\u2010Cohn M. A.","year":"2021","journal-title":"Free Neuropathology"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-021-00412-3"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12960"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12593"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701\u2010016\u20102744\u20101"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1549029"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010018\u20101623\u20101"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature26000"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajns.AJNS_315_20"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.5414\/np300411"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12967"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:37:59Z","timestamp":1754397479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.70016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/neup.70016"],"URL":"https:\/\/doi.org\/10.1111\/neup.70016","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"assertion":[{"value":"2025-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70016"}}