{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:59:56Z","timestamp":1789095596249,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Pituitary blastoma is a rare embryonal tumor of the pituitary gland, typically occurring in children under 2\u2009years of age and strongly associated with germline DICER1 mutations. Only a limited number of cases have been reported, with very few occurring beyond early childhood. We present the case of a 27\u2010year\u2010old male who presented with severe headaches, vomiting, visual disturbances, and altered behavior. Magnetic resonance imaging revealed a large suprasellar mass with sellar extension, diffusion restriction, and hemorrhagic components. The radiological differential diagnoses included papillary craniopharyngioma, pilocytic astrocytoma, and high\u2010grade glioma. Surgical decompression was performed, and histopathological examination revealed a highly cellular tumor with blastemal, glandular, and rosette\u2010forming components, consistent with pituitary blastoma. Immunohistochemistry showed patchy positivity for OLIG2, synaptophysin, and LIN28A, along with a high Ki\u201067 proliferation index (~90%). Next\u2010generation sequencing confirmed a pathogenic DICER1 mutation (p.Glu1813Asp, p.Pro817fs), supporting the diagnosis. Unlike most reported cases, which present with Cushing's syndrome or ophthalmoplegia, this patient had an elevated prolactin level, a feature not previously described in pituitary blastoma. The tumor followed an aggressive course, and the patient succumbed within a month post\u2010surgery. This case expands the clinicopathologic spectrum of pituitary blastoma, emphasizing unusual age and known genetic associations, and highlights the need for a high index of suspicion in atypical cases.<\/jats:p>","DOI":"10.1111\/neup.70017","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T19:35:03Z","timestamp":1748806503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pituitary Blastoma: Expanding the Spectrum of Histopathological Findings in a Young Adult With <scp>DICER1<\/scp> Mutation"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3592-9533","authenticated-orcid":false,"given":"Sumanta","family":"Das","sequence":"first","affiliation":[{"name":"Department of Pathology, Agilus Diagnostics Ltd Fortis Memorial Research Institute  Gurugram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8711-2023","authenticated-orcid":false,"given":"Bheru Dan","family":"Charan","sequence":"additional","affiliation":[{"name":"Department of Radiology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6006-6309","authenticated-orcid":false,"given":"Shrinidhi","family":"Nathany","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplant, Agilus Diagnostics Fortis Memorial Research Institute  Gurugram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiology Fortis Memorial Research Institute  Gurugram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-3296","authenticated-orcid":false,"given":"Mehar Chand","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neuropathology and Neurosciences Centre All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fortis Memorial Research Institute  Gurugram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Patir","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fortis Memorial Research Institute  Gurugram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Ahlawat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Agilus Diagnostics Ltd Fortis Memorial Research Institute  Gurugram India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-011-0328-x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa857"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1285-z"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM_1193_20"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.04.096"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0688-8"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0388-9"},{"issue":"1","key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/(SICI)1097-0142(19970701)80:1<147::AID-CNCR20>3.0.CO;2-X","article-title":"Pleuropulmonary Blastoma: A Clinicopathologic Study of 50 Cases","volume":"80","author":"Priest J. 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