{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:23:36Z","timestamp":1755217416083,"version":"3.43.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Low\u2010grade glioneuronal tumors of the cranial nerves are rare, with only a few case reports describing their association with trigeminal neuralgia and no prior reports including genetic analysis. We present a case of a low\u2010grade glioneuronal tumor located adjacent to the trigeminal nerve root in a 70\u2010year\u2010old man who had been experiencing severe left\u2010sided trigeminal neuralgia for several months. He had initially presented with cranial polyneuropathy, for which oral steroid therapy was initiated. Magnetic resonance imaging of the head revealed the left superior cerebellar artery running near the left trigeminal nerve; however, no mass lesions were detected. During microvascular decompression, an 8\u2010mm white tumor was identified on the trigeminal nerve and subsequently removed. Histopathological examination of the surgical specimen revealed round tumor cells with slightly eosinophilic or vacuolated cytoplasm, arranged in nests or rosettes. Foci of calcification, hemorrhage, and hemosiderin deposition were present, but eosinophilic granular bodies, Rosenthal fibers, necrosis, pleomorphism, or mitosis was absent. The tumor cells were immunopositive for synaptophysin and anti\u2010Neuronal Nuclei, focally positive for glial fibrillary acidic protein and S\u2010100 protein, and immunonegative for Olig2 and epithelial membrane antigen, with a Ki\u201067 labeling index of &lt;\u20091%. Molecular analyses confirmed the fusion of <jats:italic>KIAA1549<\/jats:italic> exon 16 with <jats:italic>BRAF<\/jats:italic> exon 9, with no mutations detected in <jats:italic>IDH1\/2<\/jats:italic>, <jats:italic>H3F3A<\/jats:italic>, <jats:italic>BRAF<\/jats:italic> (V600), or <jats:italic>FGFR1<\/jats:italic>. These findings provide novel molecular and embryological insights into low\u2010grade glioneuronal tumors of the trigeminal nerve, which may aid in their classification and understanding of the development of the tumor and neuralgia.<\/jats:p>","DOI":"10.1111\/neup.70018","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T02:20:47Z","timestamp":1753237247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low\u2010Grade Glioneuronal Tumor Adjacent to the Fifth Cranial Nerve Root With <scp><i>KIAA1549::BRAF<\/i><\/scp> Fusion Presenting With Trigeminal Neuralgia"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9826-3384","authenticated-orcid":false,"given":"Satoko","family":"Nakada","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hokuriku Brain and Neuromuscular Disease Center, NHO Iou National Hospital  Kanazawa Japan"},{"name":"Department of Human Pathology Kanazawa University Graduate School of Medicine  Kanazawa Japan"},{"name":"Department of Pathology Toyama City Hospital  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanao","family":"Mohri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Toyama City Hospital  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Toyama City Hospital  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-7818","authenticated-orcid":false,"given":"Takuya","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Research Institute for Brain and Blood Vessels, Akita Cerebrospinal and Cardiovascular Center  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiho","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Neurology Hokuriku Brain and Neuromuscular Disease Center, NHO Iou National Hospital  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pathology Toyama City Hospital  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.180300"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.11.022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050809"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12054"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12533"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000179981.62074.b1"},{"issue":"4","key":"e_1_2_11_8_1","article-title":"Internal Auditory Canal Glioneural Hamartoma: A Rare Mass Masquerading as a Vestibular Schwannoma","volume":"15","author":"Li D.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000053100.29308.F3"},{"key":"e_1_2_11_10_1","first-page":"289","article-title":"Glioneuronal Heterotopia Presenting as Cerebellopontine Angle Tumor of Cranial Nerve VIII","volume":"14","author":"Peris\u2010Celda M.","year":"2011","journal-title":"World Neurosurgery"},{"volume-title":"WHO Classification of Tumours Editorial Board. Central Nervous System Tumours","year":"2021","author":"Tihan T.","key":"e_1_2_11_11_1"},{"volume-title":"WHO Classification of Tumours Editorial Board Central Nervous System Tumours","year":"2021","author":"Perry A.","key":"e_1_2_11_12_1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1346949"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200110000-00005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0873-8"},{"volume-title":"WHO Classification of Tumours Editorial Board Central Nervous System Tumours","year":"2021","author":"Pajtler K. W.","key":"e_1_2_11_16_1"},{"volume-title":"WHO Classification of Tumours Editorial Board Central Nervous System Tumours","year":"2021","author":"Varlet P.","key":"e_1_2_11_17_1"},{"volume-title":"WHO Classification of Tumours Editorial Board Central Nervous System Tumours","year":"2021","author":"Hainfellner J. A.","key":"e_1_2_11_18_1"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2097"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0551-z"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1882-3"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2007.00773.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00523-z"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:37:55Z","timestamp":1754397475000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.70018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/neup.70018"],"URL":"https:\/\/doi.org\/10.1111\/neup.70018","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"2025-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70018"}}