{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:43:57Z","timestamp":1771235037014,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Diffuse hemispheric glioma, H3 G34\u2010mutant (DHG), is a newly defined pediatric\u2010type tumor in the 2021 WHO classification of central nervous system (CNS) tumors. DHGs harbor missense mutations at codon 35 of <jats:italic>H3F3A<\/jats:italic> (H3.3 G35R\/V mutations) and exhibit diverse histopathological features, such as glioblastomas or CNS embryonal tumors. Regardless of histological variation, they demonstrate uniform immunohistochemical and molecular findings: Olig2 negative, ATRX loss, p53 positive, and <jats:italic>MGMT<\/jats:italic> promoter methylated. These tumors occur predominantly in the cerebral hemispheres of adolescents and young adults, while they are extremely rare in middle\u2010aged and elderly individuals. Here, we report a middle\u2010aged case of DHG with prominent perivascular invasion. The tumor initially demonstrated a focal glioblastoma\u2010like area, whereas the recurrent tumor predominantly showed perivascular spread of spindle cells. We reviewed previously reported DHG cases in middle\u2010aged and elderly patients and compared their clinicopathological features with those of adolescents and young adults.<\/jats:p>","DOI":"10.1111\/neup.70022","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T03:14:26Z","timestamp":1753240466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diffuse Hemispheric Glioma, <scp>H3 G34<\/scp>\u2010Mutant With Prominent Perivascular Invasion in a Middle\u2010Aged Man: A Case Report and Literature Review of Middle\u2010Aged and Elderly Cases"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-4000","authenticated-orcid":false,"given":"Sayaka","family":"Yuzawa","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Asahikawa Medical University Hospital  Asahikawa 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