{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:27:35Z","timestamp":1765844855741,"version":"3.48.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We performed a systematic review of the literature to better define the scope of MYB alterations in angiocentric glioma and their associated clinical characteristics, as well as to include a novel\n                    <jats:italic>MYB<\/jats:italic>\n                    mutation in an angiocentric glioma case. We also review MYB alterations in the context of oncologic disease. Following PRISMA guidelines, we searched PubMed and Web of Science for relevant literature from 2010 to October 2024. Included articles reported original data on human subjects with angiocentric glioma and a detected\n                    <jats:italic>MYB<\/jats:italic>\n                    mutation. We include one additional angiocentric glioma case showcasing a novel\n                    <jats:italic>MYB<\/jats:italic>\n                    mutation. A total of 14 studies met the inclusion criteria, with a total of 114 patients with individual data for pooled analysis. The mean age was 10.3\u2009years (SD \u00b19.7\u2009years); 60% of patients were male.\n                    <jats:italic>MYB::QKI<\/jats:italic>\n                    was the most common fusion in 68% of patients. Other\n                    <jats:italic>MYB<\/jats:italic>\n                    mutations included MYB rearrangements,\n                    <jats:italic>MYB::ESR1<\/jats:italic>\n                    ,\n                    <jats:italic>MYB::PCDHGA1<\/jats:italic>\n                    ,\n                    <jats:italic>MYB::LOC105378099<\/jats:italic>\n                    , and\n                    <jats:italic>MYB::MMP16<\/jats:italic>\n                    . The most common anatomical location was in the cerebral cortex in 68% of patients.\n                    <jats:italic>MYB<\/jats:italic>\n                    fusions in other relevant neuro\u2010oncologic diseases highlight the importance of\n                    <jats:italic>MYB<\/jats:italic>\n                    fusions in adenoid cystic carcinomas, which frequently occur at the skull base, head and neck, and breast. In conclusion, we characterize the breadth of angiocentric glioma patterns in terms of demographics, anatomic location, and\n                    <jats:italic>MYB<\/jats:italic>\n                    fusion patterns. The updated molecular diagnosis of angiocentric glioma as of 2021 warrants continued exploration of the scope of\n                    <jats:italic>MYB<\/jats:italic>\n                    oncogene fusions as drivers of prognosis and targets for future therapies.\n                  <\/jats:p>","DOI":"10.1111\/neup.70036","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:53:48Z","timestamp":1763600028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MYB Alterations in Angiocentric Gliomas"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-9252","authenticated-orcid":false,"given":"Isabela","family":"Pe\u00f1a Pino","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Center for Skull Base and Pituitary Surgery University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Yohan","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Center for Skull Base and Pituitary Surgery University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Center for Skull Base and Pituitary Surgery University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7103-4182","authenticated-orcid":false,"given":"Samuel W.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hennepin County Medical Center  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4249-565X","authenticated-orcid":false,"given":"William E.","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darby","family":"Bedell","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam L.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-0493","authenticated-orcid":false,"given":"Andrew S.","family":"Venteicher","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Center for Skull Base and Pituitary Surgery University of Minnesota  Minneapolis Minnesota 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