{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:01:43Z","timestamp":1773025303244,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Malignant transformation of craniopharyngioma is an exceptionally rare and poorly characterized phenomenon. We report a case of a 15\u2010year\u2010old girl who developed symptom recurrence 9\u2009years after undergoing surgery and radiotherapy for adamantinomatous craniopharyngioma. Histology revealed malignant areas comprising highly proliferative basaloid cells with abrupt transitions into ghost cells, resembling ghost cell odontogenic carcinoma. We conducted a literature review and pooled case analysis of 45 cases, which showed a median benign\u2010to\u2010malignant latency of 10\u2009years and a median overall survival of 9\u2009months. The majority of benign diagnoses were adamantinomatous type. Prior radiotherapy was noted in 27 cases (60%). Histological findings of malignant components were reported as unspecified malignant transformation in 20 cases (44.4%), squamous cell carcinoma (SCC) in 16 cases (35.6%), odontogenic\u2010type carcinomas in 5 cases (11.1%), and other types in 4 cases (8.9%). Immunohistochemical analyses showed consistent positivity for pan\u2010cytokeratin, p63, and p40 in all cases performed. The p53 and Ki\u201067 also consistently exhibited increased or abnormal expression. Due to the overlapping histological and immunohistochemical features of odontogenic\u2010type carcinomas and SCC, careful assessment is recommended when diagnosing recurrent CPs.<\/jats:p>","DOI":"10.1111\/neup.70043","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T05:14:57Z","timestamp":1768799697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant Craniopharyngioma With Features Resembling Ghost Cell Odontogenic Carcinoma: A Case Report and Histopathology Literature Review"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-0720","authenticated-orcid":false,"given":"Sompon","family":"Apornvirat","sequence":"first","affiliation":[{"name":"Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"},{"name":"Department of Pathology, Thammasat University Hospital Thammasat University  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pitchayanant","family":"Laemad","sequence":"additional","affiliation":[{"name":"Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhannaporn","family":"Limsuksrikul","sequence":"additional","affiliation":[{"name":"Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phirasit","family":"Chaijitrawan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Thammasat University Hospital Thammasat University  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Putch","family":"Phairintr","sequence":"additional","affiliation":[{"name":"Department of Pathology, Thammasat University Hospital Thammasat University  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raywat","family":"Noiphithak","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Faculty of Medicine Thammasat University  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Central Nervous System Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0125-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.11.111"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000380"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000634"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001292"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.25259\/SNI_664_2021"},{"key":"e_1_2_9_9_1","volume-title":"Head and Neck Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2023"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.09.021"},{"issue":"8","key":"e_1_2_9_11_1","first-page":"843","article-title":"Malignant Changes in a Craniopharyngioma","volume":"15","author":"Akachi K.","year":"1987","journal-title":"No Shinkei Geka Neurological Surgery"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198802000-00029"},{"issue":"6","key":"e_1_2_9_13_1","first-page":"723","article-title":"Craniopharyngioma With Malignant Transformation\u2014A Report of Two Cases","volume":"35","author":"Suzuki F.","year":"1989","journal-title":"Gan no Rinsho Japan Journal of Cancer Clinics"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-5868(99)90019-X"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-1356-MC"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688690400012400"},{"issue":"4","key":"e_1_2_9_17_1","first-page":"345","article-title":"Treatment of Craniopharyngiomas in Children","volume":"32","author":"Sakai K.","year":"2004","journal-title":"No Shinkei Geka. 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