{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T08:45:58Z","timestamp":1777020358411,"version":"3.51.4"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    IDH\u2010mutant gliomas most commonly harbor the canonical\n                    <jats:italic>IDH1<\/jats:italic>\n                    p.R132H mutation, followed by less common mutations involving\n                    <jats:italic>IDH1<\/jats:italic>\n                    p.R132 or\n                    <jats:italic>IDH2<\/jats:italic>\n                    p.R172 codons. We present a case of a 32\u2010year\u2010old male found to have a left temporal brain tumor with regional enhancement on brain MRI, for which he underwent resection. Histologic sections showed an infiltrating astrocytic tumor with increased mitotic activity and elevated Ki67 (MIB1) labeling. The tumor was negative for IDH1 p.R132H mutant protein expression with retained ATRX expression. 1p\/19q was intact by FISH analysis, and next\u2010generation sequencing identified a previously unreported\n                    <jats:italic>IDH2<\/jats:italic>\n                    (p.R172_H173delinsSN) likely pathogenic variant. A diagnosis of astrocytoma, IDH\u2010mutant, CNS WHO grade 3 was rendered. Subsequent tumor methylation profiling performed at the National Institutes of Health matched with high confidence to the class \u201cIDH glioma, subclass astrocytoma\u201d and confirmed lack of\n                    <jats:italic>MGMT<\/jats:italic>\n                    promoter hypermethylation. He received adjuvant concurrent radiation and temozolomide. Surveillance brain MRI at 32\u2009months post resection demonstrated no evidence of interval tumor progression. We present a case of IDH\u2010mutant astrocytoma with a somewhat atypical molecular presentation, including a previously uncharacterized\n                    <jats:italic>IDH2<\/jats:italic>\n                    mutation, retained ATRX expression, and lack of\n                    <jats:italic>MGMT<\/jats:italic>\n                    promoter hypermethylation. Though it has not been biochemically or functionally validated, tumor methylation profiling is supportive of this previously uncharacterized\n                    <jats:italic>IDH2<\/jats:italic>\n                    variant as tumorigenic.\n                  <\/jats:p>","DOI":"10.1111\/neup.70048","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:05:09Z","timestamp":1772993109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of\n                    <scp>IDH<\/scp>\n                    \u2010Mutant Astrocytoma Harboring an\n                    <scp>IDH2<\/scp>\n                    R172_H173delinsSN Variant"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1247-6917","authenticated-orcid":false,"given":"Thomas","family":"Auen","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Shonka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Oncology and Hematology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahara","family":"Cathcart","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2021\u20100295\u2010CP"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010020\u201003662\u2010x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12187"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a025894"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(10)70053\u2010X"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000967\u20107"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00509"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304194"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/neup.70048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T08:04:04Z","timestamp":1777017844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.70048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/neup.70048"],"URL":"https:\/\/doi.org\/10.1111\/neup.70048","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"2025-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70048"}}