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Many of these are attributed to viruses, for example, carcinomas with the presence of transcriptionally active high\u2010risk human papillomavirus, as well as Epstein\u2013Barr virus associated malignant lymphoepithelial carcinoma and haematolymphoid neoplasias. Olfactory neuroblastoma (ONB) is a rare malignant tumor of the olfactory fossa with an unknown etiology. We present the first comprehensive virus study of ONB. By targeted next\u2010generation sequencing for 41 DNA viruses, we investigated the presence of papillomaviruses, herpesviruses, polyomaviruses, and parvoviruses, among others, in 12 ONBs. In addition, herpesvirus presence was evaluated by qPCR. Low\u2010risk HPV6 was detected in one sample. Human endogenous retroviruses were positive in all samples, supporting successful library preparation and sequencing, considered as an internal quality control. No other virus findings were observed. The present broad\u2010scale virus study did not reveal abundant presence of viral DNA in ONB suggesting a limited viral role in its etiology. Nevertheless, our cohort exhibited a finding of low\u2010risk HPV, which has been associated with increased risk of cancer progression of inverted sinonasal papilloma in the same anatomic site advocating for further research.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    \u00a731\/07.03.2019\n                  <\/jats:p>","DOI":"10.1111\/neup.70055","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:25:56Z","timestamp":1774362356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>DNA<\/scp>\n                    Virus Detection in Olfactory Neuroblastomas Using Targeted Enrichment\n                    <scp>NGS<\/scp>"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2310-039X","authenticated-orcid":false,"given":"Maria K.","family":"Jauhiainen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Helsinki University Hospital and University of Helsinki  Helsinki Finland"},{"name":"Department of Virology University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Research Program in Systems Oncology, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi I.","family":"Mielonen","sequence":"additional","affiliation":[{"name":"Department of Virology University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Department of Pathology Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaro","family":"Haapaniemi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Helsinki University Hospital and University of Helsinki 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Otorhinolaryngology\u2014Head and Neck Surgery Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0451-2404","authenticated-orcid":false,"given":"Antti A.","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Helsinki University Hospital and University of Helsinki  Helsinki Finland"},{"name":"Research Program in Systems Oncology, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology Karolinska Institute and Karolinska University Hospital  Stockholm 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