{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:42:15Z","timestamp":1792082535829,"version":"4.4.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K14759"],"award-info":[{"award-number":["23K14759"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Japanese encephalitis (JE) is a mosquito\u2010borne viral infection of the central nervous system for which no specific antiviral treatment is available. We report the case of a 79\u2010year\u2010old man residing in Kumamoto Prefecture, southwestern Japan, with JE who presented with fever, impaired consciousness, and respiratory failure, and subsequently died of multiple organ failure despite early supportive care. Magnetic resonance imaging (MRI) revealed characteristic bilateral thalamic lesions, leading to an early clinical suspicion of JE before serological confirmation. Neuropathological findings, particularly, the involvement of the thalamus, substantia nigra, hippocampus, and anterior horn of the spinal cord, were consistent with previously reported cases of JE, while also demonstrating a broader distribution of lesions than suggested by antemortem MRI. As most cases of JE occur in unvaccinated individuals, vaccination should be considered in middle\u2010aged and older adults, particularly, those with low antibody titers against the JE virus.<\/jats:p>","DOI":"10.1111\/neup.70068","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:36:38Z","timestamp":1783143398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Japanese Encephalitis With a Characteristic Neuropathological Distribution Following Early\n                    <scp>MRI<\/scp>\n                    \u2010Based Diagnosis: An Autopsy Case"],"prefix":"10.1111","volume":"46","author":[{"given":"Yujiro","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Neurology Ariake Medical Center  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Neurology Ariake Medical Center  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8931-8861","authenticated-orcid":false,"given":"Keiichi","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasa","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3242-0988","authenticated-orcid":false,"given":"Fumi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kumamoto University Hospital  Kumamoto Japan"},{"name":"Department of Pathology and Cell Biology University of the Ryukyus  Ginowan Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1371-2547","authenticated-orcid":false,"given":"Hirotake","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Pathology Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-7368","authenticated-orcid":false,"given":"Hironori","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6814-0582","authenticated-orcid":false,"given":"Mitsuharu","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.26902"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010361"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010009\u20105249\u20105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u2010510x(99)00318\u20104"},{"issue":"2","key":"e_1_2_12_6_1","first-page":"153","article-title":"The Pathology of Japanese Encephalitis. A Review","volume":"30","author":"Miyake M.","year":"1964","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100404.1997.tb00250.x"},{"issue":"5","key":"e_1_2_12_8_1","first-page":"965","article-title":"The Pathology of Japanese B Encephalitis","volume":"22","author":"Zimmerman H. M.","year":"1946","journal-title":"American Journal of Pathology"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00918"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.4.405"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3126\/ajms.v12i10.37395"},{"key":"e_1_2_12_12_1","unstructured":"National Institute of Infectious Diseases \u201cJapan: Japanese Encephalitis Antibody Carriage Status by Age\/Year \u201d2023 cited January 5 2025 https:\/\/www.niid.go.jp\/niid\/images\/epi\/yosoku\/2023\/Seroprevalence\/je2023serum.pdf."}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70068","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/neup.70068","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:14:15Z","timestamp":1787555655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.70068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/neup.70068"],"URL":"https:\/\/doi.org\/10.1111\/neup.70068","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"assertion":[{"value":"2026-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70068"}}