{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:23:20Z","timestamp":1787556200427,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202411003"],"award-info":[{"award-number":["SZSM202411003"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report a rare case of oligosarcoma, IDH\u2010mutant, arising from a recurrent astrocytoma in a male in his 50s. The patient was originally diagnosed with IDH\u2010mutant astrocytoma, CNS WHO grade 2, lacking 1p\/19q co\u2010deletion. At recurrence, the tumor exhibited a pure spindle cell sarcoma morphology, with retained IDH1 R132H, ATRX, and TP53 mutations, homozygous CDKN2A\/B deletion, and a methylation profile classifying it as oligosarcoma, IDH\u2010mutant. Although next\u2010generation sequencing (NGS) suggested non\u2010specific partial 1p\/19q deletion signals, a true whole\u2010arm 1p\/19q co\u2010deletion was not confirmed by fluorescence in\u00a0situ hybridization (FISH) or methylation\u2010based copy\u2010number analysis, as shown in Figure\u00a04E. Only two prior reports describe oligosarcoma arising from astrocytoma. Based on the sarcomatous morphology, astrocytic molecular background, and methylation clustering, we interpret this case as post\u2010treatment sarcomatous transformation of an IDH\u2010mutant astrocytoma, CNS WHO grade 2, rather than a canonical oligosarcoma. This case highlights the limitations of methylation profiling in heavily treated gliomas and underscores the importance of multimodal molecular confirmation in diagnostically challenging tumors.<\/jats:p>","DOI":"10.1111\/neup.70069","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:21:28Z","timestamp":1783477288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sarcomatous Transformation of an\n                    <scp>IDH<\/scp>\n                    \u2010Mutant Astrocytoma With an Oligosarcoma\u2010Like Methylation Profile"],"prefix":"10.1111","volume":"46","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pathology, Shenzhen Second People's Hospital Shenzhen University 1st Affiliated Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shenzhen Second People's Hospital Shenzhen University 1st Affiliated Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiology Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shenzhen Second People's Hospital Shenzhen University 1st Affiliated Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1998.89.3.0425"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2019.1699903"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213378.94547.ae"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2024.03.028"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-024-02715-z"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-024-01908-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature26000"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02529-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02395-z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-025-02905-3"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/neup.70069","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:14:13Z","timestamp":1787555653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.70069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/neup.70069"],"URL":"https:\/\/doi.org\/10.1111\/neup.70069","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70069"}}