{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:03:34Z","timestamp":1791821014702,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>CIC<\/jats:italic>\n                    \u2010rearranged sarcoma is a rare, aggressive tumor entity with a dismal outcome. We describe a patient with a history of B\u2010cell acute lymphoblastic leukemia (B\u2010ALL), presenting to our hospital with seizures and left\u2010sided upper limb weakness. Brain imaging revealed a localized right frontal mass, which was surgically resected. Initial pathological analyses suggested a secondary malignant neoplasm, not otherwise specified. However, the tumor's methylome was profiled and analyzed using the DKFZ brain tumor classifier to reach a diagnosis of\n                    <jats:italic>CIC<\/jats:italic>\n                    \u2010rearranged sarcoma, confirmed by FISH study. The patient received the ICE protocol, alongside focal radiotherapy. The patient experienced a local recurrence 14\u2009months post\u2010diagnosis. The brain tumor classifier significantly improved the efficiency of diagnosing this rare tumor in a pediatric patient. However, effective therapeutic regimens for\n                    <jats:italic>CIC<\/jats:italic>\n                    \u2010rearranged sarcomas remain unavailable.\n                  <\/jats:p>","DOI":"10.1111\/neup.70070","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:41:33Z","timestamp":1784122893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary Intracranial\n                    <i>CIC<\/i>\n                    \u2010Rearranged Sarcoma With Prior History of B\u2010Cell\n                    <scp>ALL<\/scp>\n                    : A Case Report"],"prefix":"10.1111","volume":"46","author":[{"given":"Rama","family":"Aburass","sequence":"first","affiliation":[{"name":"Office of Scientific Affairs and Research (OSAR) King Hussein Cancer Center  Amman 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