{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:23:19Z","timestamp":1787556199998,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K14490"],"award-info":[{"award-number":["JP23K14490"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Glioblastoma is the most common primary malignant central nervous system (CNS) tumor; however, its microenvironment, including tumor\u2010associated microglia\/macrophages (TAMs), is not fully understood. Although ionized calcium\u2010binding adaptor molecule 1 (IBA\u20101) is expressed in various microglial phenotypes in the healthy human brain, CD163 is a marker of activated\/phagocytic microglia. Tissues from 34 patients with glioblastoma were analyzed, and 17.6% of cases were CD163\u2010dominant. CD163\u2010dominant patients showed better overall survival than IBA\u20101\u2010dominant patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019). CD163 dominance was identified as an independent prognostic factor for overall survival (hazard ratio [HR], 0.17;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.011). Compared with the IBA\u20101\u2010dominant group, CD163\u2010dominant tumors showed more CD4\u2010positive cell infiltration (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005), fewer ameboid TAMs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021), and fewer non\u2010microvascular proliferation (non\u2010MVP) vessels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012). No significant differences were found in patient characteristics, such as age, sex, tumor location, or extent of resection. The CD163\u2010to\u2010IBA\u20101 ratio of TAMs is a significant independent prognostic factor in glioblastoma, suggesting that the activation status of these cells and their interactions with the vascular endothelium and T cells influence tumor progression. These findings highlight TAMs as potential therapeutic targets for glioblastoma.\n                  <\/jats:p>","DOI":"10.1111\/neup.70071","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:00:55Z","timestamp":1784253655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CD163<\/scp>\n                    Dominance Within Macrophages\/Microglia Reflects a Favorable Prognosis in Patients With Glioblastoma"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-0473","authenticated-orcid":false,"given":"Mayuko","family":"Moritsubo","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-7818","authenticated-orcid":false,"given":"Takuya","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"},{"name":"Department of Neurosurgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4693-1359","authenticated-orcid":false,"given":"Hidenobu","family":"Yoshitake","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Negoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-1258","authenticated-orcid":false,"given":"Motohiro","family":"Morioka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-3725","authenticated-orcid":false,"given":"Hiroaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440010502"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12354"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173090"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlaa058"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nly124"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-023-04447-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858414530512"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113109"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108041"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14060413"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-026-02999-3"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17091457"},{"key":"e_1_2_11_15_1","first-page":"10","article-title":"A Quantitative Digital Analysis of Tissue Immune Components Reveals an Immunosuppressive and Anergic Immune Response With Relevant Prognostic Significance in Glioblastoma","volume":"10","author":"Idoate Gastearena M. 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