{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:23:20Z","timestamp":1787556200021,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Non\u2010diffuse large B\u2010cell lymphomas (non\u2010DLBCL) of the central nervous system (CNS) are rare and diagnostically challenging. This study aims to characterize the clinical, radiological, and pathological features of non\u2010DLBCL CNS lymphomas diagnosed at a tertiary care center over 13\u2009years, highlighting diagnostic pitfalls. A retrospective review was conducted of non\u2010DLBCL CNS lymphoma cases diagnosed at Sunnybrook Health Sciences Centre, Toronto, from 2010 to 2022. Clinical, demographic, and radiological data were extracted from medical records. Imaging was reviewed by a neuroradiologist, and histopathological slides and molecular data were re\u2010evaluated by a pathology team. Additional tests were performed to update classifications per the 5th edition of the WHO Classification of Haematolymphoid Tumors. Seventeen cases were identified (11 males, 6 females; age 38\u201376), compared to 72 DLBCL cases during the same period. Nine cases were extra\u2010axial and eight intra\u2010axial. Eight were primary and nine secondary CNS lymphomas. B\u2010cell lymphomas (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200913) included extra\u2010nodal marginal zone lymphoma (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096), follicular lymphoma, mantle cell lymphoma, CLL, intravascular large B\u2010cell lymphoma (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092), EBV+ LBCL, and polymorphic PTLD. T\u2010cell lymphomas (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094) included PTCL, NOS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092), ALK\u2010negative ALCL, and secondary mycosis fungoides. Imaging revealed four major patterns, and symptoms were largely due to mass effect. This case series emphasizes the considerable heterogeneity of non\u2010DLBCL CNS lymphomas and the diagnostic challenges they present. It highlights key features that can aid recognition and improve diagnostic accuracy for these rare CNS entities.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    SUN\u20105771\n                  <\/jats:p>","DOI":"10.1111\/neup.70072","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:21:42Z","timestamp":1785907302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A 13\u2010Year Review of Non\u2010Diffuse Large B Cell Lymphomas of the Central Nervous System at a Tertiary Hospital: A Case Series Study"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-2058","authenticated-orcid":false,"given":"Niloofar","family":"Sina","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Center, Laboratory Medicine and Pathobiology University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Heyn","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Sunnybrook Health Sciences Center, Medical Imaging University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeina","family":"Ghorab","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Center, Laboratory Medicine and Pathobiology University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Keith","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Center, Laboratory Medicine and Pathobiology University of Toronto  Toronto 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