{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:17:31Z","timestamp":1787890651849,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Caveolin\u20101 (Cav\u20101) is a component of the vesicle\u2010like structure of the plasma membrane called caveolae. Cav\u20101 is involved in the transport of substances from the plasma membrane to the intracellular space of various cells. It has been reported that it is involved in the growth mechanisms, angiogenesis, and immune evasion of various malignant tumors. In the present study, the relationships between Cav\u20101 expression in primary central nervous system lymphomas (PCNSLs) and clinicopathological characteristics were investigated to clarify the role of Cav\u20101 in the progression of PCNSLs and patient prognosis. The expression of Cav\u20101 was assessed in 39 PCNSLs (CNS diffuse large B\u2010cell lymphomas) using immunostaining, and its prognostic significance was evaluated. Cav\u20101 expression by PCNSLs was evaluated using the histoscore (H\u2010score). The H\u2010score for Cav\u20101 in PCNSLs ranged from 0 to 90 (median 20); there were 12 cases showing no score (H\u2010score 0), 11 cases with a low score (0\u2009&lt;\u2009H\u2010score\u2009&lt;\u200920), and 16 cases with a high score (H\u2010score\u2009\u2265\u200920). Survival was significantly lower in patients with high H\u2010scores than in those with no score and low H\u2010scores (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), and in patients with high numbers of Cav\u20101\u2010positive vessels than in those with low numbers of Cav\u20101\u2010positive vessels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Cav\u20101 positivity in tumor cells was correlated with the Ki\u201067 labeling index and the number of Cav\u20101\u2010positive vessels. These results suggest that Cav\u20101 may be involved in the proliferation and angiogenesis of PCNSL cells. The present study also demonstrated that overexpression of Cav\u20101 in PCNSLs is associated with tumor progression and a poor patient prognosis.\n                  <\/jats:p>","DOI":"10.1111\/neup.70076","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:40:28Z","timestamp":1787888428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Expression of Caveolin\u20101 Reflects a Poor Prognosis in Patients With Primary Central Nervous System Lymphomas"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7250-457X","authenticated-orcid":false,"given":"Yasuo","family":"Sugita","sequence":"first","affiliation":[{"name":"Department of Neuropathology Neurology Center, St. Mary's Hospital  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-7818","authenticated-orcid":false,"given":"Takuya","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-0473","authenticated-orcid":false,"given":"Mayuko","family":"Moritsubo","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Neurology Center, St. Mary's Hospital  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Higaki","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Mary's Hospital  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brain Research Institute Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-0277","authenticated-orcid":false,"given":"Akiyoshi","family":"Kakita","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brain Research Institute Niigata University  Niigata Japan"},{"name":"Center for Human Brain Resource Initiative (ChBRI) Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12030"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.644336"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555\u2010020\u201009890\u2010x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060968"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.3.10.1147"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.06.044"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2009.29"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21137"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.22633"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20102066\u20103"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31819ed0b7"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414\u2010431X2020e10653"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14065"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5038"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253\u2010008\u20109144\u20107"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10867"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010022\u201001807\u20108"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258951"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2012.09148.x"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212241"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.255"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142682"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6156"},{"key":"e_1_2_13_25_1","first-page":"350","volume-title":"WHO Classification of Tumours. 5th Edition Central Nervous System Tumours","author":"Deckert M.","year":"2021"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2022.2133541"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.13264"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010006\u20109281\u20103"},{"key":"e_1_2_13_29_1","first-page":"617","article-title":"Expression of Cyclooxygenease\u20102 and Vascular Endothelial Growth Factor in Primary Central Nervous System Lymphomas","volume":"18","author":"Sugita Y.","year":"2007","journal-title":"Oncology Reports"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.8.23.10138"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11022"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010022\u201009275\u2010z"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5308"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.08.030"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010024\u201002401\u20109"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010022\u201000976\u20103"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.171"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.12.010"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/neup.70076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:40:30Z","timestamp":1787888430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.70076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/neup.70076"],"URL":"https:\/\/doi.org\/10.1111\/neup.70076","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"2026-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70076"}}