{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:07:30Z","timestamp":1789546050018,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Non\u2010meningothelial mesenchymal tumors (NMMTs) of the central nervous system (CNS) are rare and diagnostically challenging neoplasms. Although World Health Organization (WHO) updates have incorporated molecularly defined entities, a subset of tumors remains difficult to classify because of overlapping morphology, nonspecific immunophenotype, and absence of canonical gene fusions. We report a supratentorial NMMT tumor in a 40\u2010year\u2010old man presenting with progressive left\u2010sided paresthesia. Neuroimaging demonstrated a parasagittal mass. Following gross total resection, histological examination revealed a predominantly myxoid proliferation with focal cortical and dural infiltration. Immunohistochemistry was noncontributory, showing focal CD99 expression. Fluorescence in\u00a0situ hybridization excluded EWSR1, FUS, and CIC rearrangements. Extended RNA\u2010based next\u2010generation sequencing identified a putative low\u2010confidence\n                    <jats:italic>SHISA5::BRAF<\/jats:italic>\n                    fusion. This case illustrates the persistent diagnostic complexity of NMMTs despite integrated histological and molecular evaluation. The absence of canonical alterations not only complicates classification but also contributes to uncertainty regarding prognosis and optimal therapeutic strategies. Emerging evidence suggests that a subset of these tumors may be driven by alternative oncogenic mechanisms, including MAPK pathway activation beyond currently recognized fusion\u2010defined entities. In this context, the identification of a putative\n                    <jats:italic>SHISA5::BRAF<\/jats:italic>\n                    fusion expands the molecular spectrum of these neoplasms, although its functional relevance remains uncertain. These challenges underscore the need for cautious long\u2010term follow\u2010up and individualized multidisciplinary management.\n                  <\/jats:p>","DOI":"10.1111\/neup.70079","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:47:54Z","timestamp":1789544874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010Meningothelial Mesenchymal Tumor of the Central Nervous System: Case Report and Literature Review"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3199-844X","authenticated-orcid":false,"given":"Laura","family":"Bauluz","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Marcos\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"},{"name":"IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9828-3886","authenticated-orcid":false,"given":"David","family":"Castanedo","sequence":"additional","affiliation":[{"name":"IDIVAL  Santander Spain"},{"name":"Department of Radiology Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4443-5888","authenticated-orcid":false,"given":"Carlos","family":"Vel\u00e1squez","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"},{"name":"IDIVAL  Santander Spain"},{"name":"Department of Anatomy and Cell Biology Universidad de Cantabria  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noad149","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2016\u20132020","volume":"25","author":"Ostrom Q. 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X.","year":"2023","journal-title":"Frontiers in Oncology"},{"issue":"6","key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1158\/1535-7163.MCT-20-0861","article-title":"BRAF V600E\/V600K Mutations Versus Nonstandard Alterations: Prognostic Implications and Therapeutic Outcomes","volume":"20","author":"Nikanjam M.","year":"2021","journal-title":"Molecular Cancer Therapeutics"},{"issue":"4","key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11523-020-00735-9","article-title":"Clinical Relevance of BRAF V600E Mutation Status in Brain Tumors With a Focus on a Novel Management Algorithm","volume":"15","author":"Kowalewski A.","year":"2020","journal-title":"Targeted Oncology"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/neup.70079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:47:59Z","timestamp":1789544879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/neup.70079"],"URL":"https:\/\/doi.org\/10.1111\/neup.70079","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]},"assertion":[{"value":"2026-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70079"}}