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This cross\u2010sectional study investigated 114 people living with HIV<\/jats:styled-content> who were taking antiretroviral medication using the HIV<\/jats:styled-content>\/AIDS<\/jats:styled-content>\u2010related S<\/jats:styled-content>tigma S<\/jats:styled-content>cale (C<\/jats:styled-content>hinese version), the S<\/jats:styled-content>ocial S<\/jats:styled-content>upport R<\/jats:styled-content>ating S<\/jats:styled-content>cale, the C<\/jats:styled-content>enter for E<\/jats:styled-content>pidemiological S<\/jats:styled-content>tudies D<\/jats:styled-content>epression S<\/jats:styled-content>cale, and the M<\/jats:styled-content>edical O<\/jats:styled-content>utcomes S<\/jats:styled-content>tudy\u2013HIV<\/jats:styled-content> health survey. Multiple linear regression analyses were used to examine the mediation effect of the psychosocial factors on health\u2010related quality of life. Results showed that stigma and social support did not have direct effects, but indirect effects on health\u2010related quality of life through a full mediation effect of depressive symptoms. The results indicate that interventions targeting depression might be the most effective approach to improving health\u2010related quality of life among people living with HIV<\/jats:styled-content> who are taking antiretroviral medication in C<\/jats:styled-content>hina.<\/jats:p>","DOI":"10.1111\/nhs.12181","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T13:57:39Z","timestamp":1418306259000},"page":"250-256","source":"Crossref","is-referenced-by-count":10,"title":["Mediation analysis of health\u2010related quality of life among people living with HIV<\/scp> infection in C<\/scp>hina"],"prefix":"10.1111","volume":"17","author":[{"given":"Xianhong","family":"Li","sequence":"first","affiliation":[{"name":"Xiangya School of Nursing Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Wang","sequence":"additional","affiliation":[{"name":"Xiangya School of Nursing Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher P","family":"Fennie","sequence":"additional","affiliation":[{"name":"Robert Stempel College of Public Health and Social Work Florida International University Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[{"name":"Xiangya School of Nursing Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Bartley","family":"Williams","sequence":"additional","affiliation":[{"name":"School of Nursing UCLA Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540120802241863"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator\u2013mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations","volume":"6","author":"Baron RM","year":"1986","journal-title":"J. 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