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Existing studies often investigate the factors in isolation without a theoretical framework. The purpose of the present study was to provide preliminary results on how cognition, physical performance, and behavioral and psychological symptoms of dementia mediate the relationship of aerobic fitness and ADL in AD. A cross\u2010sectional analysis was used (<jats:italic>n<\/jats:italic>\u2009=\u200928: average age 78 [8] years, education 16 (3) years, Mini\u2010Mental State Examination scores 20 [4]). The results showed that aerobic fitness is not linked to ADL directly, and its association with ADL was mediated by physical performance and global cognition. Our findings provide preliminary support for aerobic fitness as a potential therapeutic target, as enhanced aerobic fitness could simultaneously modify other factors affecting ADL. Nurses are in a unique position for coordinating exercise safety assessment and prescription and educating older adults with AD about exercise participation.<\/jats:p>","DOI":"10.1111\/nhs.12426","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T02:10:15Z","timestamp":1525745415000},"page":"14-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cognitive and physical factors affecting daily function in Alzheimer's disease: A cross\u2010sectional analysis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-1987","authenticated-orcid":false,"given":"Fang","family":"Yu","sequence":"first","affiliation":[{"name":"School of Nursing University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Taihe Hospital  Shiyan Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Mathiason","sequence":"additional","affiliation":[{"name":"School of Nursing University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoqin","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Nursing Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng V.","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Nursing University of Rochester Medical Center  Rochester New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617714000344"},{"key":"e_1_2_8_3_1","volume-title":"ACSM's resource manual for guidelines for exercise testing and prescription","author":"American College of Sports Medicine","year":"2014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610212002360"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2011.08.042"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2015.06.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2011.11.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131862"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2012.10.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.06.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2012.09.008"},{"issue":"6","key":"e_1_2_8_12_1","first-page":"M177","article-title":"Functional status and clinical findings in patients with Alzheimer's disease","volume":"47","author":"Freels S.","year":"1992","journal-title":"Journal of Gerontology Series A Biological Sciences and Medical Sciences"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.53.5.471"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2013.11.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.M85"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10705519909540118"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205011666140317101419"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.2.233"},{"key":"e_1_2_8_19_1","volume-title":"Principles and practice of structural equation modeling","author":"Klein R. 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