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This systematic review explores the impact of at\u2010home interventions for caregivers supporting individuals with advanced illness, examining intervention characteristics and methodological quality. Quantitative studies published over the past 5\u2009years (2019\u20132024) were sourced from PubMed, PsycINFO, CINAHL, Scopus, and Cochrane Library. Intervention data, including modality, components, timing, providers, recipients, and caregiver outcomes, were systematically reviewed. Methodological quality was assessed using Cochrane RoB 2 and ROBINS\u2010I. From 16 studies, key caregiver needs such as depression, anxiety, distress, quality of life, burden, and caregiving self\u2010efficacy emerged as primary areas addressed. The majority of interventions were face\u2010to\u2010face, nurse\u2010led, and aimed at primary caregivers. Findings underscore the importance of personalized interventions that consider caregivers' unique responses and actively involve them in design. Nurses play a crucial role in leading these interventions, positioning them as central to enhancing caregiver support in home settings.<\/jats:p>","DOI":"10.1111\/nhs.70196","type":"journal-article","created":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T23:20:35Z","timestamp":1755472835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Interventions for Caregivers Caring for a Family Member With Advanced Illness at Home: A Systematic Review"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1134-0348","authenticated-orcid":false,"given":"Leire","family":"Sevillano\u2010Garayoa","sequence":"first","affiliation":[{"name":"Nursing Care for Adult Patients Department, Faculty of Nursing University of Navarra  Pamplona Spain"},{"name":"Innovation for a Person\u2010Centred Care Research Group, Faculty of Nursing University of Navarra  Pamplona Spain"},{"name":"Alpha Gamma Alpha Chapter #623  Navarra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8354-8367","authenticated-orcid":false,"given":"Maddi","family":"Olano\u2010Lizarraga","sequence":"additional","affiliation":[{"name":"Nursing Care for Adult Patients Department, Faculty of Nursing University of Navarra  Pamplona Spain"},{"name":"Innovation for a Person\u2010Centred Care Research Group, Faculty of Nursing University of Navarra  Pamplona Spain"},{"name":"Alpha Gamma Alpha Chapter #623  Navarra Spain"},{"name":"Navarra's Health Research Institute (IdiSNA)  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3795-8389","authenticated-orcid":false,"given":"Jes\u00fas","family":"Mart\u00edn\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Nursing Care for Adult Patients Department, Faculty of Nursing University of Navarra  Pamplona Spain"},{"name":"Innovation for a Person\u2010Centred Care Research Group, Faculty of Nursing University of Navarra  Pamplona Spain"},{"name":"Alpha Gamma Alpha Chapter #623  Navarra Spain"},{"name":"Navarra's Health Research Institute (IdiSNA)  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2020.03.012"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2014.18.159.2995"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00018"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare\u20102015\u2010000878"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216320931341"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2019.04.011"},{"key":"e_1_2_14_8_1","volume-title":"Family Caregiving Across the Life Span","author":"Berg C.","year":"2021"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909120968257"},{"key":"e_1_2_14_10_1","first-page":"269","volume-title":"Annual Symposium Proceedings. 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