{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:24:06Z","timestamp":1773282246416,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010flow nasal cannula (HFNC) therapy is widely used for respiratory support within paediatrics, most commonly used as a supportive measure in acute respiratory failure, aiming to avoid invasive mechanical ventilation (IMV). It is increasingly being used following extubation of critically ill children potentially at a higher risk of requiring re\u2010intubation. Less data indicate the use for post\u2010extubation HFNC therapy or possible clinical outcomes of this therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims and objectives<\/jats:title><jats:p>To identify reasons for, and variables to predict, the use of HFNC therapy post\u2010extubation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This was a retrospective case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All children admitted to a nine\u2010bedded regional paediatric intensive care unit requiring IMV between 18 December 2017 and 28 November 2018 were identified. The demographic data and bedside clinical and laboratory variables of the patients requiring HFNC therapy were compared with those who did not require HFNC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no statistical difference in the median age and weight of children receiving HFNC therapy post\u2010extubation compared with children not receiving it. In a logistic regression model, the highest ventilation (peak inspiratory pressure) and oxygen requirements in the first 24\u2009hours of admission, along with the presence of comorbidity and use of HFNC therapy prior to intubation, predicted the use of HFNC following extubation, (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> 0.42, area under the receiver operating curve 0.843, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The direct correlation between high initial ventilatory requirements and pre\u2010existing comorbidity was significant for the use of post\u2010extubation HFNC therapy. This may be useful to stratify children in the use of HFNC therapy post\u2010extubation in the critically ill population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to clinical practice<\/jats:title><jats:p>This study provides evidence that it may be possible to predict the use of HFNC therapy post\u2010extubation. Avoiding unnecessary use of this therapy improves patient care while providing a positive economic impact.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nicc.12509","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T04:34:26Z","timestamp":1586925266000},"page":"42-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predicting use of high\u2010flow nasal cannula therapy following extubation in paediatrics"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9254-996X","authenticated-orcid":false,"given":"Deborah K.","family":"White","sequence":"first","affiliation":[{"name":"Paediatric Intensive Care Unit Cambridge University Hospitals NHS Foundation Trust, Box 7, Addenbrooke's Hospital  Cambridge UK"},{"name":"Department of Paediatrics Cambridge University, Box 116, Addenbrooke's Hospital  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther S.","family":"Daubney","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit Cambridge University Hospitals NHS Foundation Trust, Box 7, Addenbrooke's Hospital  Cambridge UK"},{"name":"Department of Paediatrics Cambridge University, Box 116, Addenbrooke's Hospital  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit Cambridge University Hospitals NHS Foundation Trust, Box 7, Addenbrooke's Hospital  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riaz","family":"Kayani","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit Cambridge University Hospitals NHS Foundation Trust, Box 7, Addenbrooke's Hospital  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazima","family":"Pathan","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit Cambridge University Hospitals NHS Foundation Trust, Box 7, Addenbrooke's Hospital  Cambridge UK"},{"name":"Department of Paediatrics Cambridge University, Box 116, Addenbrooke's Hospital  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-014-0029-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001100"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-2871"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001805"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2015-204914"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijccm.IJCCM_181_17"},{"key":"e_1_2_9_8_1","article-title":"Is treatment with a high flow nasal cannula effective in acute viral bronchiolitis? 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