{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:31:31Z","timestamp":1768818691708,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite increased attention, acute and persistent post\u2010operative pain are not treated efficiently and interventions against acute pain are therefore of clinical importance and should be welcomed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims and objectives<\/jats:title><jats:p>To evaluate the effectiveness of wound infiltration with 0.5% bupivacaine for pain management in the immediate post\u2010operative period in patients that underwent cardiac surgery with sternotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The study was performed employing a single\u2010centre nonrandomized experimental design to evaluate a prospective cohort of patients recruited from June to December of 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre study with a non\u2010randomized experimental design compared the pain perceived by 137 patients undergoing to cardiac surgery within which 68 patients who received infiltration of bupivacaine and 69 patients received infiltration with saline solution. Pain measures were made with the numeric rating scale (NRS) at 2, 12, 24, and 48\u2009hours. Socio\u2010demographic and clinical variables were included too and descriptive, bivariate, and multivariate logistic regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant difference was found between the means of the NRS scores in favour of the intervention group. Cohen's <jats:italic>d<\/jats:italic> showed a significant effect size. NRS scores were grouped into NRS \u22654 or NRS &lt;4 and similar results were found. Multivariate logistic regression analyses showed the absence of confounding factors that could call results into question.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subcutaneous infiltration of 0.5% bupivacaine in the surgical site of patients who have undergone cardiac surgery showed clinically and statistically significant pain relief compared with patients who received saline infiltration throughout the first 12\u2009hours after surgery. This intervention provides promising preliminary results that, alone or in conjunction with other nursing interventions, could constitute an important therapeutic tool for this area of nursing clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nicc.12614","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:46:17Z","timestamp":1614559577000},"page":"223-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bupivacaine infiltration for acute postoperative pain management after cardiac surgery"],"prefix":"10.1111","volume":"27","author":[{"given":"Manuel","family":"Luque Oliveros","sequence":"first","affiliation":[{"name":"Departamento de Enfermer\u00eda Universidad de Sevilla  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0717-3938","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Morilla Romero de la Osa","sequence":"additional","affiliation":[{"name":"Departamento de Enfermer\u00eda Universidad de Sevilla  Seville Spain"},{"name":"Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cient\u00edficas, Universidad de Sevilla  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60245-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujps.2011.08.013"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.07.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.05.021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474515114550441"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjane.2014.09.013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.03.076"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000258"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659113488433"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000255040.71600.41"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2011.08.001"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001576"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.05.029"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9204"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.123227"},{"issue":"2","key":"e_1_2_10_17_1","first-page":"172","article-title":"Bupivacaine in the management of postoperative pain associated with inguinal hernia repair","volume":"67","author":"Pag\u00e1n A","year":"2000","journal-title":"Cir Esp"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02748.x"},{"key":"e_1_2_10_19_1","unstructured":"Joanna Briggs Institute.Critical Appraisal tools: Checklist for Quasi\u2010Experimental Studies (non\u2010randomized experimental studies).https:\/\/joannabriggs.org\/ebp\/critical_appraisal_tools. Accessed January 10 2018"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2005.01121.x"},{"key":"e_1_2_10_21_1","volume-title":"IBM SPSS Statistics for Windows. [computer program]. Version 20.0","author":"IBM Corp","year":"2011"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200303000-00006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.998"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30352-6"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.13329"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474515116631680"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474515111430879"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.148314"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.09.006"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S211042"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.10.004"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2005.200318.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcnurse.2011.05.002"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000139652.84897.BD"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.039"},{"issue":"2","key":"e_1_2_10_36_1","first-page":"79","article-title":"How to control confounding effects by statistical analysis","volume":"5","author":"Pourhoseingholi MA","year":"2012","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.4415\/ANN_16_02_09"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.397"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.01.020"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e318240957f"},{"issue":"4","key":"e_1_2_10_41_1","first-page":"477","article-title":"The efficacy of preventive parasternal single injection of bupivacaine on intubation time, blood gas parameters, narcotic requirement, and pain relief after open heart surgery: a randomized clinical trial study","volume":"16","author":"Saeidi M","year":"2011","journal-title":"J Res Med Sci"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2016.11.011"}],"container-title":["Nursing in Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nicc.12614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nicc.12614","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nicc.12614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:42:51Z","timestamp":1693006971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nicc.12614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,28]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/nicc.12614"],"URL":"https:\/\/doi.org\/10.1111\/nicc.12614","archive":["Portico"],"relation":{},"ISSN":["1362-1017","1478-5153"],"issn-type":[{"value":"1362-1017","type":"print"},{"value":"1478-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,28]]},"assertion":[{"value":"2020-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}