{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:11:51Z","timestamp":1790748711261,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antimicrobial resistance is a threat to global public health. The use of prolonged infusions in the hospital setting for certain antimicrobials is widely increasing in order to improve their efficacy and safety, including resistance development. Due to limited vascular access, it is important to clarify whether they can be infused through the same line with other drugs during Y\u2010site administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this review is to update and summarize the evidence on Y\u2010site compatibility of antibacterial agents administered as prolonged infusions in intensive care units (ICUs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A literature review of PubMed, EMBASE and Trissel's Handbook on Injectable Drugs databases was conducted on the compatibility of selected antimicrobials administered simultaneously at a Y\u2010site connection with parenteral nutrition and other widely used drugs in ICUs. All articles published up to October 30, 2021, in English or Spanish were included, regardless of the type of publication (original articles, case reports, letters, etc.). Eligible antimicrobials were those that can be administered as prolonged infusions: ceftazidime, cefepime, piperacillin\/tazobactam, meropenem, ceftolozane\/tazobactam, ceftaroline, cloxacillin, ceftobiprole, vancomycin and fosfomycin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1302 drug\u2010to\u2010drug potential combinations were explored, 196 (15.05%) were found to be incompatible, and in 541 (41.55%), data were not available. The results were presented in a simple 2\u2010dimensional consultation chart as a quick reference for health care professionals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review provides useful and reliable information on the compatibility of antimicrobials administered as Y\u2010site infusion with other drugs commonly used in the critical setting. This review contributes to patient safety in nursing practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to Clinical Practice<\/jats:title><jats:p>To our knowledge, this is the first review on Y\u2010site compatibility of antimicrobials used as prolonged infusions with other commonly used drugs, including anti\u2010emetics, analgesics and anti\u2010epileptic and parenteral nutrition. The results of the current review need to be addressed to promote the knowledge sharing between health professionals and improve the quality and safety of patients. We believe that this review may serve as a simple and effective 2\u2010dimensional updated drug\u2010to\u2010drug compatibility reference chart for critical care nurses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nicc.12754","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T04:19:45Z","timestamp":1643343585000},"page":"849-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Compatibility of prolonged infusion antibiotics during Y\u2010site administration"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-4207","authenticated-orcid":false,"given":"Mar\u00eda","family":"Nunez\u2010Nunez","sequence":"first","affiliation":[{"name":"Pharmacy Department University Hospital Cl\u00ednico San Cecilio  Granada Spain"},{"name":"Biomedical Research Institute of Granada (Ibs.Granada)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Murillo\u2010Izquierdo","sequence":"additional","affiliation":[{"name":"Pharmacy Department University Hospital Virgen Macarena  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Moya\u2010Martin","sequence":"additional","affiliation":[{"name":"Pharmacy Department University Hospital Virgen Macarena  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malvina","family":"Hoxha","sequence":"additional","affiliation":[{"name":"Department of Chemical\u2010Toxicological and Pharmacological Evaluations of Drugs Catholic University Our Lady of Good Counsel  Tirane Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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