{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:44:38Z","timestamp":1791186278278,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nitroglycerin (NTG)\u2010induced headache is the most common side effect of nitrate therapy and negatively affects the quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the preventive and severity\u2010reducing effect of cold compresses applied to the bilateral frontotemporal and occipital regions, where pain is most frequently experienced, for headache among individuals receiving intravenous NTG treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>This research used an observational, two\u2010group, pretest\u2013posttest design and was completed from October 2020 to May 2021 in the coronary intensive care unit of a state hospital located in the north of Turkey. The first group in the research had cold compresses applied for 20\u2009min with the aid of an applicator at the start of NTG infusion, while the second group had the same implementation when headache developed during infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups were similar in terms of the demographic and clinical features of participants. In our study, more headache was observed in the group without local cold compresses at the start of infusion (53.3%) compared with the group with local cold compresses at the start of infusion (25.8%) (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a04.841, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.028). In both groups, the heart rate, systolic and diastolic blood pressure values of patients significantly approached normal values after cold compresses. Patients with local cold compresses applied when headache developed had significantly different visual analog scale scores before (5.75) and after (2.00) the cold compresses application (<jats:italic>z<\/jats:italic>\u00a0=\u00a03.558, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At the beginning of the infusion, local cold compresses application may prevent NTG\u2010induced headache in patients without headache, and local cold compresses applied when headache develops may reduce the severity of NTG\u2010induced headache.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to Clinical Practice<\/jats:title><jats:p>Application of cold compresses immediately when treatment begins is recommended as a simple and effective practice with no side effects for patients receiving NTG treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nicc.12823","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:50:10Z","timestamp":1657932610000},"page":"1097-1105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effect of local cold compresses for <scp>nitroglycerin\u2010induced<\/scp> headache: An observational <scp>pretest\u2013posttest<\/scp> study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0096-5593","authenticated-orcid":false,"given":"Yasemin Kalkan","family":"U\u011furlu","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Medical Nursing Department Ordu University  Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-9124","authenticated-orcid":false,"given":"Nuray","family":"En\u00e7","sequence":"additional","affiliation":[{"name":"Florence Nightingale Faculty of Nursing, Medical Nursing Department Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.33808\/clinexphealthsci.595444"},{"issue":"7","key":"e_1_2_13_3_1","first-page":"237","article-title":"Randomized controlled trial: targeted neck cooling in the treatment of the migraine patient","volume":"72","author":"Sprouse\u2010Blum AS","year":"2013","journal-title":"Hawai'i J Med Public Health"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nel035"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-16-5"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331979604700707"},{"issue":"46","key":"e_1_2_13_7_1","first-page":"2323","article-title":"Nitroglycerin\u2010induced headaches","volume":"145","author":"Juh\u00e1sz G","year":"2004","journal-title":"Orv Hetil"},{"key":"e_1_2_13_8_1","volume-title":"Nitroglycerin StatPearls","author":"Kim KH","year":"2021"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194\u2010008\u20100043\u20109"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20102982.2006.01257.x"},{"issue":"3","key":"e_1_2_13_11_1","first-page":"116","article-title":"Effect of applying reflexology massage on nitroglycerin\u2010induced migraine\u2010type headache: a placebo\u2010controlled clinical trial","volume":"30","author":"Imani N","year":"2018","journal-title":"Agr\u0131 J Turk Soc Algol"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0592-1"},{"issue":"2","key":"e_1_2_13_13_1","first-page":"12","article-title":"Pain assessment in intensive care nursing and nursing management","volume":"4","author":"Alakan Y\u015e","year":"2017","journal-title":"Hacet Univ Fac Health Sci J"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.79689"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.10.1059"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207459808986453"},{"key":"e_1_2_13_17_1","first-page":"1","article-title":"The methods for reducing pain due to intramuscular injection","volume":"2","author":"Kara D","year":"2013","journal-title":"G\u00fcm\u00fc\u015fhane Univ J Health Sci"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1054\/ctnm.1999.0429"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7489(00)00061-4"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01709.x"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000434754"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.5578\/khj.10343"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.4770130405"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-018-1041-8"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2018.01.006"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2016.05.006"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.05.025"},{"issue":"4","key":"e_1_2_13_28_1","first-page":"32","article-title":"Effect of interactive distraction versus cutaneous stimulation for venipuncture pain relief in school age children","volume":"5","author":"Abd El SM","year":"2015","journal-title":"J Nurs Educ Pract"},{"issue":"1","key":"e_1_2_13_29_1","first-page":"27","article-title":"Cold therapy and the effect on pain and physiological parameters in patients recovering from spine surgery: a randomized prospective study","volume":"28","author":"Akta\u015f YY","year":"2021","journal-title":"Complement Med Res"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnss.2016.12.007"},{"issue":"1","key":"e_1_2_13_31_1","first-page":"1050","article-title":"Effect of foot reflexology versus cryotherapy on pain associated with arterial puncture among critically ill children","volume":"7","author":"Badr EA","year":"2020","journal-title":"Int J Novel Res Healthc Nurs"},{"issue":"4","key":"e_1_2_13_32_1","first-page":"214","article-title":"Effect of application of ice pack on reducing pain during the arterial puncture","volume":"14","author":"Khalil N","year":"2017","journal-title":"Clin Pract"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.21608\/mnj.2021.180678"},{"issue":"2","key":"e_1_2_13_34_1","first-page":"53","article-title":"A\u011fr\u0131 tedavisinde hem\u015firenin rol\u00fc","volume":"14","author":"\u00c7\u00f6\u00e7elli LP","year":"2008","journal-title":"Gaziantep T\u0131p Dergisi"}],"container-title":["Nursing in Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nicc.12823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nicc.12823","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nicc.12823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T16:30:32Z","timestamp":1698683432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nicc.12823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/nicc.12823"],"URL":"https:\/\/doi.org\/10.1111\/nicc.12823","archive":["Portico"],"relation":{},"ISSN":["1362-1017","1478-5153"],"issn-type":[{"value":"1362-1017","type":"print"},{"value":"1478-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,15]]},"assertion":[{"value":"2022-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}