{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:04:37Z","timestamp":1780085077751,"version":"3.54.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Globally, sepsis has been identified as one of the leading causes of preventable childhood mortality and morbidity. Previous studies on intensive care patients estimated that approximately 30% of children with sepsis experience some form of disability at discharge. Development of care has seen growing numbers of children treated for sepsis not requiring a PICU admission; however, outcomes in this population are yet to be understood. Further focus is required to understand sepsis survivorship across the wider population to address knowledge gaps and morbidity burden in the broader surviving population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the cognitive, physical, emotional and social health of children surviving sepsis 2\u2009years after hospital discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective, observational cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and thirty\u2010two children will be screened, 2\u2009years after their hospital admission, and approached for participation in this study. Children who are &lt;18\u2009years of age at follow\u2010up, treated for sepsis\u2010related organ dysfunction or septic shock in Queensland between October 2018 and December 2019, will be included. Children who are deceased at follow\u2010up, under care of the state, or require English interpreters will be excluded from participation. Data will be collected through an online follow\u2010up survey comprising validated caregiver\u2010reported questionnaires covering the four Post Intensive Care Syndrome\u2010paediatrics (PICS\u2010p) domains (cognitive, physical, emotional and social health; Manning et al. Pediatr Crit Care Med, 2018, 19, 298\u2013300).<\/jats:p><jats:p>The primary outcome is an adaptive behaviour of the participants assessed using the Vinelands\u20103 tool. Secondary outcomes will include neurodevelopment, quality of life, child distress, overall function, executive function, caregiver's distress and caregiver's stress. Analysis of variance (ANOVA), Kruskal\u2010Wallis and Fisher's exact test\/chi\u2010squared tests will be used for statistical analyses. No adjustments will be made for multiple comparisons but it is acknowledged that comparisons made in this study are exploratory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to Clinical Practice<\/jats:title><jats:p>With more children surviving sepsis, there is a need for a more comprehensive assessment of patient and family outcomes to allow support structures for families leaving the hospital after sepsis. This study is expected to inform clinicians and stakeholders of patient and family well\u2010being after sepsis survivorship.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nicc.12938","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T05:50:06Z","timestamp":1686376206000},"page":"438-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term outcomes after paediatric sepsis (LOTUS)\u2013A protocol for an Australian cohort study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6551-9098","authenticated-orcid":false,"given":"Jessicah","family":"Minogue","sequence":"first","affiliation":[{"name":"School of Nursing Centre for Healthcare Transformation, QUT  Brisbane Australia"},{"name":"Neonatal Critical Care Unit Mater Mother's Hospital  South Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luregn J.","family":"Schlapbach","sequence":"additional","affiliation":[{"name":"Child Health Research Centre The University of Queensland  Brisbane Australia"},{"name":"Department of Intensive Care and Neonatology, and Children's Research Center University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2797-4388","authenticated-orcid":false,"given":"Samantha","family":"Keogh","sequence":"additional","affiliation":[{"name":"School of Nursing Centre for Healthcare Transformation, QUT  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Child Health Research Centre The University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Long","sequence":"additional","affiliation":[{"name":"School of Nursing Centre for Healthcare 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