{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:41:35Z","timestamp":1775979695015,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Amiodarone is a prophylactic rhythm\u2010regulating drug used to prevent arrhythmia; However, especially during infusion, it has the potential to cause a number of complications, especially phlebitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of the study is to determine the effects of sesame oil, which has the potential to prevent phlebitis that may occur during amiodarone infusion administered to patients after cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This prospective, two\u2010arm (1:1), block randomized controlled interventional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was conducted with 44 patients treated in the coronary intensive care unit of a university hospital, who received parenteral infusion of amiodarone. Sesame oil was applied superficially by applying 10 drops to a 10\u2009cm perimeter of the cannula for 10\u2009min. This application was repeated every 8\u2009h during the 24\u2010h amiodarone infusion. No intervention was made to the patients in the control group. However, standard nursing care measures and a standard transparent dressing were applied to the patients in both groups during the peripheral catheter application phase. Patients in the intervention and control groups were evaluated in terms of phlebitis at the end of every 24\u2009h using the Visual Infusion Phlebitis Scale. The study was reported according to the CONSORT declaration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Phlebitis symptoms occurred in 15\/22 (68.2%) of the patients in the intervention group on the first day, 3\/22 (13.6%) on the second day and 2\/22 (9.1%) of the patients on the third day, while in the control group, 20\/22 (90.9%) of the patients had phlebitis on the first day and 2\/22 (9.1%) on the second day. The incidence of phlebitis was 20\/22 (90.9%) in the intervention group and 22\/22 (100%) in the control group. There was no statistically significant difference in phlebitis symptoms between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The research results showed that the application of sesame oil did not significantly reduce the frequency of phlebitis. However, a trend indicating delayed onset of phlebitis symptoms was observed in the sesame oil group. Nevertheless, larger sample studies are needed. These studies are expected to assist in determining the effects of sesame oil on phlebitis more precisely and provide stronger support for the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>Training of nurses on non\u2010pharmacological methods should be supported and opportunities should be given for their application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.13085","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T03:38:15Z","timestamp":1714189095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of open\u2010label sesame oil applied to cardiac surgery patients in preventing amiodarone\u2010induced phlebitis: A randomized controlled trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8356-8202","authenticated-orcid":false,"given":"Muaz","family":"G\u00fcl\u015fen","sequence":"first","affiliation":[{"name":"Surgical Nursing Department, Faculty of Health Sciences \u00c7ukurova University  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-9391","authenticated-orcid":false,"given":"Sevban","family":"Arslan","sequence":"additional","affiliation":[{"name":"Surgical Nursing Department, Faculty of Health Sciences \u00c7ukurova University  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u20102700.62111"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/wvn.12470"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-9066.157840"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4037\/ccn2012139"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4700257"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4037\/ajcc2013460"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijn.12976"},{"key":"e_1_2_12_9_1","first-page":"459","article-title":"Occurrence of phlebitis in patients on intravenous amiodarone","volume":"6","author":"Martinho R","year":"2008","journal-title":"Einstein"},{"issue":"12","key":"e_1_2_12_10_1","first-page":"1279","article-title":"The 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Y","year":"2016","journal-title":"J Hum Rhythm"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.13040\/IJPSR.0975\u20108232.4(11).4442\u201047"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.6.218"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.20527\/jbk.v13i2.4067"},{"issue":"1","key":"e_1_2_12_21_1","first-page":"21","article-title":"Comparing the effect of warm moist compress and calendula ointment on the severity of phlebitis caused by 50% dextrose infusion: a clinical trial","volume":"6","author":"Jourabloo N","year":"2017","journal-title":"Med Surg Nurs J"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.6018\/eglobal.16.1.260411"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.11997\/nitcwm.202002026"},{"issue":"4","key":"e_1_2_12_24_1","first-page":"1065","article-title":"Effect of external use of sesame oil in the prevention of chemotherapy\u2010induced phlebitis","volume":"11","author":"Nekuzad N","year":"2012","journal-title":"Iran J Pharmaceut Res"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2019.01.016"},{"issue":"4","key":"e_1_2_12_26_1","first-page":"198","article-title":"Pasdaran, the efficacy and safety of sesame oil in prevention of chemotherapy\u2010induced phlebitis in children with acute lymphoblastic leukemia","volume":"7","author":"Mosayebi SZ","year":"2017","journal-title":"Iran J Pediatr Hematol Oncol"},{"key":"e_1_2_12_27_1","unstructured":"SumbulogluK AkdagB.\u0130leri Biyoistatistiksel Y\u00f6ntemler. 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