{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:04:58Z","timestamp":1791327898662,"version":"4.3.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Catheter\u2010related thrombosis is a common complication of the peripherally inserted central catheter (PICC) in neonates, leading to unintended tube removal and significantly affecting neonatal health and safety. Despite widespread reporting on the estimated occurrence and factors contributing to neonatal PICC\u2010related thrombosis, these findings have not been synthesized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The purpose of this study was to determine the incidence and risk factors of neonatal PICC\u2010related thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Systematic literature review and meta\u2010analysis. Two independent researchers systematically explored multiple databases\u2014such as PubMed, Medline, Embase and the Cochrane Library\u2014from their inception until October 2023. Our study aggregates and scrutinizes studies specifically addressing the incidence and risk factors of neonatal PICC\u2010related thrombosis. Employing the RevMan 5.3 software, a meta\u2010analysis was executed to determine the incidence of both thrombosis and odds ratios (OR), accompanied by their respective 95% confidence intervals (CI) for the risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 327 articles were screened, and data from 24 studies were used in synthesis. Neonatal PICC\u2010related thrombosis incidence varied from 0.23% to 17.91%. The pooled incidence was 2% (95% CI: 1%\u20132%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200994%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). The study identified 12 risk factors, including insertion sites in the lower extremities (OR\u2009=\u20090.22; 95% CI: 0.09\u20130.56;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001), gestational age &lt;28\u2009weeks, abdominal pathology, fresh frozen plasma by day 5\u2009&gt;\u200950\u2009mL\/kg, PICC tip location (proximal placement), two lumens, three lumens, prolonged hospital stay, infection, mothers' use of anticoagulants, patients with cardiac insufficiency and being twin\u2010to\u2010twin transfusion syndrome donor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The analysis indicates an overall pooled incidence of neonatal PICC\u2010related thrombosis of 2%. Twelve factors were identified as risks associated with neonatal PICC\u2010related thrombosis. Understanding the risk factors can provide evidence\u2010based recommendations for improving awareness, control and treatment and better nursing management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis illuminates the incidence and risk factors linked to neonatal PICC\u2010related thrombosis, delivering essential insights pivotal for clinical decision\u2010making and enhancing patient care within neonatal health care settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.13121","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T22:39:20Z","timestamp":1720996760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Incidence and risk factors of neonatal\n                    <scp>peripherally inserted central catheter<\/scp>\n                    \u2010related thrombosis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3320-4232","authenticated-orcid":false,"given":"Xiuwen","family":"Chen","sequence":"first","affiliation":[{"name":"Teaching and Research Section of Clinical Nursing, Xiangya Hospital Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha China"},{"name":"Xiangya School of Nursing Central South University  Changsha China"},{"name":"Xiangya Research Center of Evidence\u2010based Healthcare Central South University  Changsha China"},{"name":"Xiangya Center for Evidence\u2010Based Practice &amp; Healthcare Innovation: A Joanna Briggs Institute Affiliated Group Central South University  Changsha 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