{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:09:06Z","timestamp":1793351346864,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M720656"],"award-info":[{"award-number":["2022M720656"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Regional citrate anticoagulation\u2010continuous renal replacement therapy (RCA\u2010CRRT) has a wide range of applications in clinical practice, but unplanned downtime due to RCA\u2010CRRT circuit coagulation is as high as 15.75%\u201366.70%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To build a nomogram model for predicting the lifespan circuits of RCA\u2010CRRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>A prospective observational cohort study was conducted in Sichuan, China. The collected clinical data from 404 RCA\u2010CRRT sessions involving 135 patients were utilized. The patients' basic information, laboratory indicators and RCA\u2010CRRT parameters were used as independent variables, and the survival status and survival time of RCA\u2010CRRT circuits were used as dependent variables. A Cox multivariate analysis was performed to build the nomogram model for predicting the lifespan of RCA\u2010CRRT circuits. The model was validated internally and externally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median lifespan of RCA\u2010CRRT circuits was 28.0 (12.0\u201346.5) h, and the unplanned downtime rate was 23.76%. In the Cox multivariate analysis, venous pressure, haemoglobin, Sequential Organ Failure Assessment (SOFA), lactate, and blood transfusion were identified as statistically significant predictive factors for the lifespan of RCA\u2010CRRT circuits (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). Subsequently, a nomogram model for predicting the lifespan of RCA\u2010CRRT circuits was developed. The AUC values for internal and external validation within the 12\u201372\u2010h timeframe ranged from 0.648 to 0.816 and 0.613 to 0.956, respectively. Both the calibration curve and clinical decision curve demonstrated the model's good performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The nomogram model developed in this study demonstrates its efficacy in accurately predicting the lifespan circuits of RCA\u2010CRRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>Clinical nurses can use the prediction model to assess the lifespan of RCA\u2010CRRT circuits, so as to formulate a personalized RCA\u2010CRRT treatment plan for patients, thus reducing the unplanned downtime of RCA\u2010CRRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.13196","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T02:04:02Z","timestamp":1731031442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Development and validation of a nomogram for circuit lifespan of regional citrate anticoagulation\u2010continuous renal replacement therapy in intensive care patients with acute kidney injury"],"prefix":"10.1111","volume":"30","author":[{"given":"Zhongbin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Surgical Intensive Care Unit, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingai","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Surgical Intensive Care Unit, Sichuan Provincial People's Hospital, School 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