{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:38:32Z","timestamp":1787729912649,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Retinopathy is frequently seen in the neonatal intensive care unit (NICU), and its examination is a painful procedure for infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This randomized active\u2010controlled trial aimed to investigate the impact of multisensory stimulation (MSS) on neonatal pain during retinopathy of prematurity (ROP) examinations, in comparison with a white noise (WN) and control group receiving standard care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Conducted as a three\u2010arm, randomized controlled trial, the study was implemented in the NICU of a local university hospital. Recruitment spanned from July 2023 to November 2023, with preterm infants (gestational age\u2009&lt;\u200937\u2009weeks) randomly assigned to either a MSS, WN or a control group. MSS components included visual, auditory, tactile, olfactory and gustatory stimuli, all designed to create a synergistic, comforting environment for the infant during the procedure. Procedural pain, heart rate and oxygen saturation were assessed at various stages before and after ROP examinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis of 90 participants revealed that the MSS group exhibited lower Premature Infant Pain Profile (PIPP) scores than the WN and control groups (mean difference: \u22122.12, 95% confidence interval [CI]: \u22122.62 to \u22121.62; odds ratio [OR]: 0.004, 95% CI [0.001, 0.012],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Additionally, heart rates were significantly lower in the MSS group (mean difference: \u221215.3 beats\/min, 95% CI: \u221220.5 to \u221210.1; OR: 0.025, 95% CI [0.008, 0.073],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and oxygen saturation levels were higher (mean difference: 3.2%, 95% CI: 1.8% to 4.6%; OR: 1.12, 95% CI [1.05, 1.20],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) than in the other groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MSS emerges as a favourable, safe and non\u2010pharmacological intervention for pain management in ROP and similar procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>Multisensory stimulation can be effectively integrated into the routine care provided by critical care nurses during retinopathy of prematurity examinations in preterm infants. This non\u2010pharmacological intervention offers a practical approach for critical care nurses to reduce procedural pain and improve physiological stability in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.13200","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:09:31Z","timestamp":1731283771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multisensory stimulation to reduce procedural pain in retinopathy of prematurity: A randomized controlled trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9893-356X","authenticated-orcid":false,"given":"Halil Ibrahim","family":"Tasdemir","sequence":"first","affiliation":[{"name":"Burdur Health Services Vocational School Burdur Mehmet Akif Ersoy University  Burdur T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,10]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmu073"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.42561"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2020.103532"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010023\u201003978\u20103"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2012.08.021"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2015.04.012"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2023.10.018"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0000000000001110"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2022.05.025"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015\u20104271"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001323"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22267"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2017.10.001"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2018.04.006"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016\u20100955"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0844562118803756"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001069.pub5"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/956549"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455979"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.1029"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31802e3bd7"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2020.04.004"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2021.10393"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnn.2023.11.008"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/nop2.2094"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S212080"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2020.102904"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2021.05.005"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.17556"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/03004430.2022.2051501"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c869"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508\u2010199912000\u201000006"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098\u2010012\u20100945\u2010z"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.22088\/jbums.17.5.3"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.22088\/jbums.18.12.13"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0308022617709761"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2007.07.012"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552\u20106909.2008.00307.x"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2014.07.002"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006\u20102277"}],"container-title":["Nursing in Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nicc.13200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nicc.13200","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nicc.13200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:21:18Z","timestamp":1773411678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nicc.13200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,10]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/nicc.13200"],"URL":"https:\/\/doi.org\/10.1111\/nicc.13200","archive":["Portico"],"relation":{},"ISSN":["1362-1017","1478-5153"],"issn-type":[{"value":"1362-1017","type":"print"},{"value":"1478-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,10]]},"assertion":[{"value":"2024-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13200"}}